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Biocompatibility evaluation of N,O-hexanoyl chitosan as a biodegradable hydrophobic polycation for controlled drug release

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Abstract

N,O-hexanoyl chitosan (HC) displayed unique properties of excellent processibility, solubility in common organic solvents and cationic characteristics, thereby might find versatile applicaions for biomedical engineering. In this study, the biocompatibility of HC was evaluated. The effect of HC on dermal fibroblast attachment, proliferation and viability was examined in vitro, in comparison with poly(lactide-co-glycolide) (PLGA) and chitosan. The in vivo tissue response to HC was compared with PLGA implanted subcutaneously; the weight loss of the implant materials was also measured duing the degradation process. It was found that HC had no deleterious effect on the viability of dermal fibroblast. In vivo, HC displayed a favorable tissue response profile compared with PLGA, with significantly less inflammation and fibrosis. The erosion rate of HC could be modulated by changing the degree of substitution of hexanoyl groups in HC.

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Acknowledgments

The project was supported by National Natural Science Foundation of China under Project 20304013.

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P.R. China

    Chaonan Xu & Hongliang Jiang

  2. Department of Biomedical Engineering, State University of New York, Stony Brook, NY, 11794, USA

    Hui Pan & Weiliam Chen

  3. Department of Chemistry, Zhejiang University, Hangzhou, 310027, P.R. China

    Guping Tang

Authors
  1. Chaonan Xu
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  2. Hui Pan
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  3. Hongliang Jiang
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  4. Guping Tang
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Correspondence to Hongliang Jiang.

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Xu, C., Pan, H., Jiang, H. et al. Biocompatibility evaluation of N,O-hexanoyl chitosan as a biodegradable hydrophobic polycation for controlled drug release. J Mater Sci: Mater Med 19, 2525–2532 (2008). https://doi.org/10.1007/s10856-008-3392-7

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  • DOI: https://doi.org/10.1007/s10856-008-3392-7

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