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Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores

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Abstract

Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Seoul National University, Seoul, 151-742, Korea

    Chang-Jun Bae, Young-Hag Koh & Hyoun-Ee Kim

  2. Department of Dental Biomaterials, School of Dentistry, Dankook University, Cheonan, 330-714, Korea

    Hae-Won Kim

Authors
  1. Chang-Jun Bae
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  2. Hae-Won Kim
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  3. Young-Hag Koh
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  4. Hyoun-Ee Kim
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Correspondence to Hyoun-Ee Kim.

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Bae, CJ., Kim, HW., Koh, YH. et al. Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores. J Mater Sci: Mater Med 17, 517–521 (2006). https://doi.org/10.1007/s10856-006-8934-2

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  • DOI: https://doi.org/10.1007/s10856-006-8934-2

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