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On the measurement of human osteosarcoma cell elastic modulus using shear assay experiments

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Abstract

This paper presents a method for determining the elastic modulus of human osteosarcoma (HOS) cells. The method involves a combination of shear assay experiments and finite element analysis. Following in-situ observations of cell deformation during shear assay experiments, a digital image correlation (DIC) technique was used to determine the local displacement and strain fields. Finite element analysis was then used to determine the Young’s moduli of HOS cells. This involved a match of the maximum shear stresses estimated from the experimental shear assay measurements and those calculated from finite element simulations.

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Authors and Affiliations

  1. Princeton Institute for the Science and Technology of Materials, Princeton, NJ

    Yifang Cao, Randy Bly, Will Moore & Wole Soboyejo

  2. Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, 08544

    Yifang Cao, Randy Bly, Will Moore & Wole Soboyejo

  3. Department of Mechanical and Aerospace Engineering, Rutgers University, Piscataway, NJ, 08854

    Zhan Gao & Alberto M. Cuitino

Authors
  1. Yifang Cao
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  2. Randy Bly
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  3. Will Moore
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  4. Zhan Gao
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  5. Alberto M. Cuitino
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  6. Wole Soboyejo
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Correspondence to Wole Soboyejo.

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Cao, Y., Bly, R., Moore, W. et al. On the measurement of human osteosarcoma cell elastic modulus using shear assay experiments. J Mater Sci: Mater Med 18, 103–109 (2007). https://doi.org/10.1007/s10856-006-0667-8

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  • DOI: https://doi.org/10.1007/s10856-006-0667-8

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