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Machine learning-assisted design of biomedical high entropy alloys with low elastic modulus for orthopedic implants

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Abstract

This paper focuses on finding an optimum composition for the TiTaHfNbZr quinary high entropy alloy (HEA) system with an elastic modulus close to that of bone in order to attain a better biomechanical compatibility between the bone and the implant in orthopedic applications. To obtain the composition providing the desired structural match, machine learning (ML) tools were implemented in the current work instead of conventional trial-and-error methods. The ML algorithms utilized in this study were trained using experimental data available in the literature and then utilized to predict the optimum HEA compositions with the lowest elastic moduli. Consequently, the Ti23Ta10Hf27Nb12Zr28 and Ti28Ta10Hf30Nb14Zr18 compositions were predicted as the optimum HEA compositions with elastic moduli of 83.5 ± 2.9 and 87.4 ± 2.2 GPa, respectively. The materials were manufactured, and the elastic moduli were validated with nanoindentation experiments. The samples were also exposed to static immersion experiments in simulated body fluid (SBF) for 28 days to gain insight and information regarding the ion release and ensure that the new HEAs are biocompatible. The findings of the work reported herein demonstrate that the proposed ML model can successfully predict HEA compositions for an optimized biomechanical compatibility for orthopedic applications and warrant further biomedical research on the two new HEAs prior to their utility as orthopedic implant materials.

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Acknowledgements

The authors thank Dr. Hadi Jahangiri for his help with the XRD measurements and Dr. Gulsu Simsek for her help with the ICP-MS analyses conducted at the Koç University Surface Science and Technology Center (KUYTAM).

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Authors and Affiliations

  1. Department of Mechanical Engineering, Advanced Materials Group (AMG), Koç University, Istanbul, 34450, Turkey

    H. C. Ozdemir, E. Bedir & D. Canadinc

  2. Department of Materials Science and Engineering, Eskisehir Technical University, Iki Eylul Campus, Eskisehir, 26480, Turkey

    R. Yilmaz

  3. Koç University Surface Science and Technology Center (KUYTAM), Istanbul, 34450, Turkey

    M. B. Yagci

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Ozdemir, H.C., Bedir, E., Yilmaz, R. et al. Machine learning-assisted design of biomedical high entropy alloys with low elastic modulus for orthopedic implants. J Mater Sci 57, 11151–11169 (2022). https://doi.org/10.1007/s10853-022-07363-w

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