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Mechanical interlocking to improve metal–polymer adhesion in polymer-based neural electrodes and its impact on device reliability

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Abstract

The polymer–metal interface is one of the most critical parts in polymer-based neural implants in relation to their long-term reliability. In this study, we aim to suggest a feasible fabrication method using mechanical interlocking to improve polymer–metal adhesion in polymer-based neural electrodes and evaluate its impact on device reliability in vitro. Liquid crystal polymer (LCP) is selected as the base material for the polymer-based neural electrode due to its extremely low water absorption rate (<0.04 %). Test samples with mechanical interlocked interface between LCP and a noble metal are designed and fabricated using micro-patterning technologies, in this case photolithography, electroplating, and laser machining. After the metal patterns with undercut profile cross sections were fabricated using a dual photolithography process and electroplating, the LCP and the metal formed a mechanical interlocking pattern during the lamination process. In a 180° peel test, the average maximum adhesion force of the samples with and without mechanical interlocking was 19.24 and 14.27 N, respectively. In vitro accelerated soak tests, which consist of interdigitated electrode patterns and a customized system for measuring the leakage current, are carried out to evaluate the long-term reliability of the LCP-based neural electrodes. Samples with and without interlock failed after 224 and 185 days, respectively, in a 75 °C saline environment. Scanning electron microscopy images revealed that the interlocked LCP–metal interfaces remained intact after water leakage. The results demonstrate the effect of the fabrication method using mechanical interlocking, which can be applicable to other polymer-based neural electrodes for long-term implantation.

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Acknowledgements

This work was supported in part by a Grant to CABMC (Control of Animal Brain using MEMS Chip) funded by Defense Acquisition Program Administration (UD140069ID) and in part by BK21 Plus Project, Department of Electrical and Computer Engineering, SNU in 2015 and in part by Engineering-Dentistry Interdisciplinary Research grant jointly funded by College of Engineering and College of Dentistry, Seoul National University.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1119, Gwanak-ro 1, Gwanak-gu, Seoul, 151-742, Republic of Korea

    Tae Mok Gwon, Jin Ho Kim, Gwang Jin Choi & Sung June Kim

  2. Inter-University Semiconductor Research Center, Seoul National University, Seoul, Republic of Korea

    Tae Mok Gwon, Gwang Jin Choi & Sung June Kim

  3. Center for New Health Technology Assessment, National Evidence-Based Healthcare Collaborating Agency, Seoul, Republic of Korea

    Jin Ho Kim

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  1. Tae Mok Gwon
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Correspondence to Sung June Kim.

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Gwon, T.M., Kim, J.H., Choi, G.J. et al. Mechanical interlocking to improve metal–polymer adhesion in polymer-based neural electrodes and its impact on device reliability. J Mater Sci 51, 6897–6912 (2016). https://doi.org/10.1007/s10853-016-9977-5

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