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Design and in vitro evaluation of novel γ-PGA/hydroxyapatite nanocomposites for bone tissue engineering

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Abstract

In order to improve biocompatibility and cell growth, poly-γ-glutamic acid (γ-PGA) was used as an additive, and a series of γ-PGA/hydroxyapatite (γ-PGA/HAp) nanocomposites were prepared. Then the morphology, water uptake and retention abilities, in vitro degradation properties in the simulated medium, and cytotoxicity of these γ-PGA/HAp nanocomposites were investigated. The results show that the γ-PGA/HAp nanocomposites have homogenous nano-sized grains, hydrophilicity, biocompatibility, and controlled in vitro degradation, suggesting that the γ-PGA/HAp nanocomposites are novel nanostructure composites with great potential application in the field of bone tissue engineering.

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Acknowledgements

This work is financially supported by the Science and Technology Planning Project of Guangdong Province (No. 2012B010200044) and the Guangzhou Science and Technology Planning Project (No. 11C14060684). We also would like to thank Mrs. Ai-lin Zhang and her team for their assistances in SEM and TEM.

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Authors and Affiliations

  1. Guangdong Institute of Microbiology, 58th Building, Courtyard 100, Xianlie Mid Road, Yuexiu District, Guangzhou, 510070, China

    Xiulin Shu, Qingshan Shi, Jing Feng, Xiaobao Xie & Yiben Chen

  2. Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangzhou, 510070, China

    Xiulin Shu, Qingshan Shi, Jing Feng, Xiaobao Xie & Yiben Chen

  3. Guangdong Open Laboratory of Application Microbiology, Guangzhou, 510070, China

    Xiulin Shu, Qingshan Shi, Jing Feng, Xiaobao Xie & Yiben Chen

  4. State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangzhou, 510070, China

    Xiulin Shu, Qingshan Shi, Jing Feng, Xiaobao Xie & Yiben Chen

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  1. Xiulin Shu
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  2. Qingshan Shi
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  3. Jing Feng
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  4. Xiaobao Xie
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  5. Yiben Chen
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Correspondence to Qingshan Shi.

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Shu, X., Shi, Q., Feng, J. et al. Design and in vitro evaluation of novel γ-PGA/hydroxyapatite nanocomposites for bone tissue engineering. J Mater Sci 49, 7742–7749 (2014). https://doi.org/10.1007/s10853-014-8484-9

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  • DOI: https://doi.org/10.1007/s10853-014-8484-9

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