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Physicochemical characterization of terbinafine-cyclodextrin complexes in solution and in the solid state

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Abstract

Terbinafine (TB) is an allylamine derivative used as oral and topical antifungal agent. The physicochemical properties of the complexes between TB and different cyclodextrins (CDs): α-CD, β-CD, hydroxypropylβ-CD, methylβ-CD and γ-CD, have been studied in pH 12 aqueous solutions at 25 °C and in the solid state. Different phase solubility profiles of TB in the presence of CDs have been obtained: AL type for TB with hydroxypropylβ-CD and γ-CD, AP type for the complexes with methylβ-CD and α-CD, while a BS profile was found for TB-β-CD. The apparent stability constants of the complexes were calculated at 25 °C from the phase solubility diagrams. The higher increase of TB solubility, up to 200-fold, together with the higher value of the stability constant were found for the complex with methylβ-CD. Solid systems of 1:1 drug:CD molar ratio were prepared and characterised using X-ray diffraction patterns, thermal analysis and FTIR spectroscopy. The coevaporation method can be considered the best method in preparing these solid complexes. The complexes of TB with natural CDs, except with α-CD, were crystalline, whereas the methyl and hydroxypropyl derivatives gave rise to amorphous phases. Dissolution rate studies have been performed with TB-β-CD and TB-HPβ-CD complexes, showing a positive influence of complexation on the drug dissolution.

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Acknowledgements

Authors are grateful to Comisión Interministerial de Ciencia y Tecnología (Project MAT2003-08390-C02-01) for financial support and to Gobierno de Navarra for M. Uzqueda’s grant.

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Authors and Affiliations

  1. Department of Chemistry and Soil Science, Physical-Chemistry, University of Navarra, C/Irunlarrea s/n., 31008, Pamplona, Navarra, Spain

    Maite Uzqueda, Carmen Martín, Arantza Zornoza, Miguel Sánchez & Itziar Vélaz

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  1. Maite Uzqueda
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  2. Carmen Martín
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Correspondence to Itziar Vélaz.

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Uzqueda, M., Martín, C., Zornoza, A. et al. Physicochemical characterization of terbinafine-cyclodextrin complexes in solution and in the solid state. J Incl Phenom Macrocycl Chem 66, 393–402 (2010). https://doi.org/10.1007/s10847-009-9656-0

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