Abstract
Purpose
This study evaluated the effects of shock energy on the dispersion of regional ventricular repolarization (DRVR), post-shock rhythm and sinus recovery time (SRT), and the relationship between DRVR and post-shock ventricular arrhythmias.
Materials and methods
Ten open-chest dogs were anesthetized. Ventricular fibrillation (VF) was electrically induced and recorded from a 6 × 6 unipolar electrode plaque (4 mm spacing) sutured on the left ventricular epicardium. Defibrillation threshold (DFT) was determined after 20 s of VF. DRVR was measured before VF, during the earliest post-shock sinus rhythm, and during sinus rhythm 30 s following shocks. Post-shock rhythm and SRT were evaluated after energies of 100% DFT, 125% DFT, 175% DFT, and 250% DFT.
Results
In the100% DFT group, the DRVR of the earliest sinus rhythm and 30 s after successful defibrillation was not significantly different than that before VF. But the DRVRs were significantly increased in 125% DFT, 175% DFT, and 250% DFT group. DRVR after defibrillation in the 250% DFT group was higher than those in the 100% DFT and 125% DFT groups. SRT in the 250% DFT group was significantly longer than that in the other groups .The incidence of post-shock ventricular tachycardia was increased when a high-shock energy was applied (P = 0.041).
Conclusion
DRVR was increased by application of high-energy defibrillation associated with SRT prolongation. The increased DRVR may play an important role in the onset of post-shock ventricular tachycardia.
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Grants
This study was supported in part by National Natural Science Foundation of China (No. 81070266, 81000081), Shanghai Science and Technology Committee Grants (No. 08140900600, 10140903100), and by Program for Innovative Research Team of Shanghai Municipal Education Commission.
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Yang Pang, Qi Jin and Ning Zhang contributed equally to this work.
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Pang, Y., Jin, Q., Zhang, N. et al. High-energy defibrillation increases the dispersion of regional ventricular repolarization. J Interv Card Electrophysiol 32, 81–86 (2011). https://doi.org/10.1007/s10840-011-9589-6
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DOI: https://doi.org/10.1007/s10840-011-9589-6