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T peak-T end Interval as an Index of Global Dispersion of Ventricular Repolarization: Evaluations Using Monophasic Action Potential Mapping of the Epi- and Endocardium in Swine

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Abstract

The ECG interval from the peak to the end of the T wave (T peak-T end) has been used as an index of transmural dispersion of ventricular repolarization (DVR). The correlation between the T peak-T end interval and the global DVR, however, has not been well-evaluated. Methods: Monophasic action potentials (MAPs) were recorded from 51 ± 10 epicardial and 64 ± 9 endocardial sites in the left ventricles of 10 pigs, and from 41 ± 4 epicardial and 53 ± 2 endocardial sites in the right ventricles of 2 of the 10 pigs using the CARTO mapping system. The end of repolarization times over the epi- and endocardium were measured, and the end of repolarization dispersions over the epicardium (DVR-epi), over the endocardium (DVR-endo) and over both (DVR-total) were calculated. The QTpeak, QTend and T peak-T end intervals as well as the QTpeak and QTend dispersions were obtained from the simultaneously recorded 12-lead ECG.

Results: The maximal T peak-T end intervals (57 ± 7 ms) were consistent with the DVR-total (58 ± 11 ms, p > 0.05), and significantly correlated with the DVR-total (r = 0.64, p < 0.05). However, the mean T peak-T end intervals (44 ± 5 ms), and T peak-T end intervals from lead II (41 ± 6 ms) and V 5 (43 ± 5 ms) were all significantly smaller than and poorly correlated with the DVR-total, as were the QTpeak and QTend dispersions (15 ± 2 ms vs. 21 ± 4 ms).

Conclusion: The maximal T peak-T end interval may be used as a noninvasive estimate for the global DVR, but not the QTpeak and QTend dispersions, nor the mean T peak-T end interval and that from a single lead.

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Authors and Affiliations

  1. Department of Cardiology, University Hospital, Lund, Sweden

    Yunlong Xia, Yanchun Liang, Ole Kongstad, Bertil Olsson & Shiwen Yuan M.D., Ph.D.

  2. Biosense Webster/Johnson & Johnson Inc., Waterloo, Belgium

    Magnus Holm

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  1. Yunlong Xia
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  2. Yanchun Liang
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  3. Ole Kongstad
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  4. Magnus Holm
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  5. Bertil Olsson
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  6. Shiwen Yuan M.D., Ph.D.
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Correspondence to Shiwen Yuan M.D., Ph.D..

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Xia, Y., Liang, Y., Kongstad, O. et al. T peak-T end Interval as an Index of Global Dispersion of Ventricular Repolarization: Evaluations Using Monophasic Action Potential Mapping of the Epi- and Endocardium in Swine. J Interv Card Electrophysiol 14, 79–87 (2005). https://doi.org/10.1007/s10840-005-4592-4

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  • DOI: https://doi.org/10.1007/s10840-005-4592-4

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