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Incidence of Pulmonary Vein Stenosis in Patients Submitted to Atrial Fibrillation Ablation: A Comparison of the Selective Segmental Ostial Ablation vs the Circumferential Pulmonary Veins Ablation

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Abstract

Introduction: Pulmonary vein (PV) stenosis is an important complication of the AF ablation and could be underestimated if their assessment is not systematically done. Selective Segmental Ostial Ablation (SSOA) and Circunferential Pulmonary Veins Ablation (CPVA) have demonstrated efficacy in atrial fibrillation (AF) treatment. In this study the real incidence of PV stenosis in patients (pts) submitted to both SSOA and CPVA was compared.

Methods: Those pts with focal activity and normal left atrial size were submitted to SSOA, remaining pts were submitted to CPVA to treat refractory, symptomatic AF. Contrast enhanced magnetic resonance angiography (MRA) was routinely performed in all patients 4 months after the procedure.

Results: A series of 73 consecutive patients (mean age of 51 ± 11 years; 75% male) were included. SSOA was performed in 32 patients, and the remaining 41 patients underwent to CPVA, obtaining similar efficacy rates (72% vs 76% arrythmia free probability at 12 months; log rank test p = NS). Six patients had a significant PV stenosis, all in SSOA group none in CPVA group (18.8% vs 0%; p = 0.005). All patients were asymptomatic and the stenosis was detected in routine MRA. No predictors of stenosis has been identified analysing patient procedure characteristics.

Conclusion: PV stenosis is a potential complication of SSOA not seen in CPVA. The study confirms than MRA is useful for identifying patients with asymptomatic PV stenosis.

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References

  1. Haissaguerre M, Jais P, Shah DC, Garrigue S, Takahashi A, Lavergne T, Hocini M, Peng JT, Roudaut R, Clementy J. Electrophysiological end point for catheter ablation of atrial fibrillation initiatied from multiple pulmonary venous foci. Circulation 2000;101:1409–1417.

    PubMed  CAS  Google Scholar 

  2. Marrouche NF, Dresing T, Cole C, Bash D, Saad E, Balaban K, Pavia SV, Schweikert R, Saliba W, Abdul-Karim A, Pisano E, Fanelli R, Tchou P, Natale A. Circular mapping and ablation of the pulmonary vein for treatment of atrial fibrillation: Impact of different catheter technologies. J Am Coll Cardiol 2002;40:464–474.

    PubMed  Google Scholar 

  3. Pappone C, Rosanio S, Oreto G, Tocchi M, Gugliotta F, Vicedomini G, Salvati A, Dicandia C, Mazzone P, Santinelli V, Gulletta S, Chierchia S. Circumferential radiofrequency ablation of pulmonary vein ostia: A new anatomic approach for curing atrial fibrillation. Circulation 2000;102:2619–2628.

    PubMed  CAS  Google Scholar 

  4. Taylor GW, Kay GN, Zheng X, Bishop S, Ideker R et al. Pathological effects of extensive radiofrequency energy applications in the pulmonary veins in dogs. Circulation 2000;101:1736–1742.

    PubMed  CAS  Google Scholar 

  5. Yu W, Hsu T, Tai C, Tsai CF, Hsieh MH, Lin WS, Lin YK, Tsao HM, Ding YA, Chang MS, Chen SA. Acquired pulmonary vein stenosis after radiofrequency ablation of paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol 2001;12:887–892.

    Article  PubMed  CAS  Google Scholar 

  6. Arentz T, Jander N, von Rosenthal J, Blum T, Furmaier R, Gornandt L, Josef Neumann F, Kalusche D. Incidence of pulmonary vein stenosis 2 years after radiofrequency catheter ablation of refractory atrial fibrillation. Eur Heart J 2003;24:963–969.

    PubMed  Google Scholar 

  7. Saad E, Rossillo A, Saad C, Martin DO, Bhargava M, Erciyes D, Bash D, Williams-Andrews M, Beheiry S, Marrouche NF, Adams J, Pisano E, Fanelli R, Potenza D, Raviele A, Bonso A, Themistoclakis S, Brachmann J, Saliba WI, Schweikert RA, Natale A. Pulmonary vein stenosis alter radiofrequency ablation of atrial fibrillation. Functional characterization, evolution and influence of the ablation strategy. Circulation 2003;108:3102–3107.

    Google Scholar 

  8. Scharf C, Sneider M, Case I, Chugh A, Lai SW, Pelosi F Jr, Knight BP, Kazerooni E, Morady F, Oral H. Anatomy of the pulmonary veins in patients with atrial fibrillation and effects of segmental ostial ablation analyzed by computed tomography. J Cardiovasc Electrophysiol 2003;14:150–155.

    Article  PubMed  Google Scholar 

  9. Yang M, Akbari H, Reddy GP, Higgins C et al. Identification of pulmonary vein stenosis after radiofrequency ablation for atrial fibrillation using MRI. J Comput Assist Tomogr 2001;25:34–35.

    Article  PubMed  CAS  Google Scholar 

  10. Kato R, Lickfett L, Meininger G, Dickfeld T, Wu R, Juang G, Angkeow P, LaCorte J, Bluemke D, Berger R, Halperin HR, Calkins H. Pulmonary vein anatomy in patients undergoing catheter ablation of atrial fibrillation. Lessons learned by the use of Magnetic Resonance Imaging. Circulation 2003;107:2004–2010.

    Article  PubMed  Google Scholar 

  11. Pappone C, Oreto G, Lamberti F, Vicedomini G, Loricchio ML, Shpun S, Rillo M, Calabro MP, Conversano A, Ben-Haim SA, Cappato R, Chierchia S. Catheter ablation of paroxysmal atrial fibrillation using a 3D mapping system. Circulation 1999;100:1203–1208.

    PubMed  CAS  Google Scholar 

  12. Pappone C, Rosanio S, Augello G, Gallus G, Vicedomini G, Mazzone P, Gulletta S, Gugliotta F, Pappone A, Santinelli V, Tortoriello V, Sala S, Zangrillo A, Crescenzi G, Benussi S, Alfieri O. Mortality, morbidity and quality of life after circumferential pulmonary vein ablation for atrial fibrillation. J Am Coll Cardiol 2003;42:185–197.

    Article  PubMed  Google Scholar 

  13. Silva RM, Mont L, Berruezo A, Fosch X, Wayar L, Alvarenga N, Chueca E, Brugada J. Radiofrequency ablation in the treatment of focal atrial fibrillation using circumferential mapping and segmentary disconnection of pulmonary veins. Rev Esp Cardiol 2003;56:361–367.

    PubMed  Google Scholar 

  14. Saad E, Marrouche N, Saad C, Ha E, Bash D, White RD, Rhodes J, Prieto L, Martin DO, Saliba WI, Schweikert RA, Natale A. Pulmonary vein stenosis after catheter ablation of atrial fibrillation: Emergence of a new clinical syndrome. Ann Intern Med 2003;138:634–638.

    PubMed  Google Scholar 

  15. Mansour M, Ruskin J, Keane D. Efficacy and safety of segmental ostial versus circumferential extra-ostial pulmonary vein isolation for atrial fibrillation. J Cardiovasc Electrophysiol 2004;15:532–537.

    PubMed  Google Scholar 

  16. %Pappone C, Vincenzo S, Manguso F, Pappone C, Santinelli V, Manguso F, Vicedomini G, Gugliotta F, Augello G, Mazzone P, Tortoriello V, Landoni G, Zangrillo A, Lang C, Tomita T, Mesas C, Mastella E, Alfieri O. Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation 2004;109:327–334.

    PubMed  Google Scholar 

  17. Vasamreddy C, Jayam V, Bluemke DA, Calkins H et al. Pulmonary vein occlusion: An unanticipated complication of catheter ablation of atrial fibrillation using the anatomic circumferential approach. Heart Rhythm 2004;1:78–81.

    Article  PubMed  Google Scholar 

  18. Karch MR, Zrenner B, Deisenhofer I, Schreieck J, Ndrepepa G, Dong J, Lamprecht K, Barthel P, Luciani E, Schomig A, Schmitt C. Freedom from atrial tachycardia after catheter ablation of atrial fibrillation. A randomized comparison between 2 current ablation strategies. Circulation 2005;111:2875–2880.

    Article  PubMed  Google Scholar 

  19. Firstenberg M, Greenberg N, Smedira N, Prior DL, Scalia GM, Thomas JD, Garcia MJ. Doppler echo evaluation of pulmonary venous-left atrial pressure gradients: Human and numerial model studies. Am J Physiol 2000;279:H594–H600.

    CAS  Google Scholar 

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Correspondence to Lluis Mont MD, PhD.

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Santiago Nava, A. Berruezo and A. Scalise were supported in part by a Grant from the Fundació Clínic per la Recerca Biomèdica.

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Tamborero, D., Mont, L., Nava, S. et al. Incidence of Pulmonary Vein Stenosis in Patients Submitted to Atrial Fibrillation Ablation: A Comparison of the Selective Segmental Ostial Ablation vs the Circumferential Pulmonary Veins Ablation. J Interv Card Electrophysiol 14, 21–25 (2005). https://doi.org/10.1007/s10840-005-4513-6

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  • DOI: https://doi.org/10.1007/s10840-005-4513-6

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