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Endometrial compaction does not predict live birth rate in single euploid frozen embryo transfer cycles

  • Assisted Reproduction Technologies
  • Published:
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Abstract

Purpose

To evaluate whether endometrial compaction using sequential transvaginal ultrasound is associated with improved live birth rates in medicated single euploid frozen embryo transfer (FET) cycles.

Methods

Prospective observational cohort study at a private fertility clinic. Patients who underwent FETs between January and December 2018 were assessed for inclusion. The change in endometrial thickness between the end of the estrogen phase and the day before embryo transfer, measured by sequential transvaginal ultrasound, was used to categorize cycles with compaction (≥ 5%), no change, or expansion (≥ 5%). FET cycle outcomes were then compared between groups. The primary outcome was live birth. Secondary outcomes include clinical pregnancy rate and rate of spontaneous abortion.

Results

Of the 259 single euploid medicated FETs performed during the study period, only 43/259 (16.6%) of the cycles demonstrated ≥ 5% compaction, whereas 152/259 (58.7%) expanded and 64/259 (24.7%) were unchanged. Live birth rates did not differ between cycles with compaction (58.1%), no change (54.7%), or expansion (58.6%), p = 0.96. Clinical pregnancy and spontaneous abortion rates were also similar between groups.

Conclusion

The vast majority of cycles did not demonstrate endometrial compaction. Endometrial compaction is not associated with live birth rate or spontaneous abortion rate in medicated single euploid FETs in this cohort.

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Data availability

Coded data pertaining to this study are stored on a password- and firewall-protected server and can be made available if needed.

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Author information

Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Los Angeles, 10833 Le Conte Avenue 27-139 CHS, Los Angeles, CA, 90095-1740, USA

    Carrie Riestenberg, Molly Quinn & Lindsay Kroener

  2. Southern California Reproductive Center, 450 North Roxbury Drive, Suite 500, Beverly Hills, CA, 90210, USA

    Alin Akopians, Hal Danzer, Mark Surrey & Shahin Ghadir

Authors
  1. Carrie Riestenberg
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  2. Molly Quinn
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  3. Alin Akopians
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  4. Hal Danzer
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  5. Mark Surrey
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  6. Shahin Ghadir
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  7. Lindsay Kroener
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Contributions

C.R., L.K, and A.A. participated in study design. C.R. performed the data collection. C.R., M.Q., L.K., and A.A. participated in data analysis. C.R., M.Q., L.K., A.A., S.G., H.D., and M.S. participated in manuscript drafting and critical discussion.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

This study was approved by the Institutional Review Board of the University of California, Los Angeles (IRB# 18-000559).

Consent to participate

Because of the retrospective nature of this study, the UCLA IRB deemed the study to have minimal risk and waived the requirement for informed consent.

Consent for publication

Consent to publish was not required as the UCLA IRB deemed this study of minimal risk.

Code availability

Code for the data can be made available if required.

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Riestenberg, C., Quinn, M., Akopians, A. et al. Endometrial compaction does not predict live birth rate in single euploid frozen embryo transfer cycles. J Assist Reprod Genet 38, 407–412 (2021). https://doi.org/10.1007/s10815-020-02043-7

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  • DOI: https://doi.org/10.1007/s10815-020-02043-7

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