Abstract
Purpose
To investigate neonatal malformation, prematurity, and stillbirth in singleton and multiple pregnancies derived from different Assisted Reproductive Techniques (ART).
Methods
In this prospective cohort study data were collected, from private and public Spanish IVF units, during the years 2008 and 2009. During this period, 8,682 pregnancies were analysed from the initial 14,119 pregnancies reported. Pregnancies included in the study derived from IUI (n = 1,065), IVF (n = 838), ICSI (n = 5,080), FET (n = 1,404) and PGD (n = 295). This first analysis focuses primarily on neonatal malformation, prematurity, and stillbirth both in singleton and multiple pregnancies derived from different ART. Malformations were classified according to the WHO ICD 10 code.
Results
Malformations were found in 0.83 % of our newborns. No differences in malformations were observed between singletons or multiples independently of the ART used. There was a significant difference in prematurity rate among singletons depending on treatment but this association was not observed in multiple pregnancies. Stillbirth was significantly lower in singleton (0.72 %) than in multiple pregnancies (1.82 %).
Conclusions
The percentage of malformations observed in ART newborns was similar to the rate observed in the normally-conceived Spanish population. Multiplicity seems to be the most important factor associated with an increased incidence of newborn complications such as prematurity or stillbirth.
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Acknowledgments
The authors would like to thank Dr. Eleuterio Hernández for the suggestions and revision of the manuscript and Rosa Cercas for statistical support. We thank the Spanish Fertility Society (SEF) for all the support given and all the collaborating centers: CIRH, Barcelona; CER, Santander; CGB, Bilbao; Clínica Ginecol Juana Hernández, Logroño; Instituto Universitario Dexeus, Barcelona; Embriogyn, Tarragona; ESIMER, Barcelona; FIV Recoletos, Madrid; FIVMadrid, Madrid; Fundación Puigvert, Barcelona; GineFIV, Madrid; Gine 3, Barcelona; GMER, Cádiz; H. Fundación Son Llatzer, Palma di Mallorca; Hospital Virgen de las Nieves, Granada; Hospital Universitario Doce de Octubre, Madrid; Hospital Universitario La Fe, Valencia; Hospital Clinic, Barcelona; Hospital Universitario Gregorio Marañon, Madrid; Hospital Universitario La Paz, Madrid; Hospital Quirón, Barcelona; Hospital Universitario Madrid-Monteprincipe, Madrid; Hospital Universitario Vall de Hebron, Barcelona; IMARA, Barcelona; Institut de Ginecologia i Reproduccio, Barcelona; Instituto Balear Infertilidad, Palma de Mallorca; URH-García del Real, Madrid; IVI-Sevilla, Sevilla; IVI-Madrid, Madrid; IVI-Valencia, Valencia; IVI-Barcelona, Barcelona; Procreatec, Madrid.
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Capsule This report examines the impact of Assisted Reproductive Techniques (ART) on malformation in Spain. Malformations were found in 0.83 % of newborns, similar to levels in the general Spanish birth population.
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Ricciarelli, E., Bruna, I., Verdú, V. et al. Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies. J Assist Reprod Genet 30, 897–905 (2013). https://doi.org/10.1007/s10815-013-0023-0
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DOI: https://doi.org/10.1007/s10815-013-0023-0