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The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis

  • ASSISTED REPRODUCTION TECHNOLOGIES
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Objective

To evaluate the relationship between different hCG priming-to-oocyte retrieval intervals and assisted reproductive technology (ART) outcome.

Methods

We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index, Chinese biomedicine (CBM) literature database, and Chinese Journal Full-text Database for randomized controlled trials (RCTs) published up to November 2010. Data was extracted from the studies by two independent reviewers. Statistical analysis was performed with Cochrane Collaboration’s Review Manager (RevMan) 5.0.2. From extracted data, Risk Ratio (RR) with 95% confidence interval (CI) was calculated.

Results

5 RCTs totaling 895 participants were included. Oocyte maturation rate was higher in the long interval group compared with short interval group (RR, 0.67; 95% CI, 0.62–0.73). There were no significant difference between the two groups with regard to fertilization rate (RR, 0.99; 95% CI, 0.94–1.04), implantation rate (RR, 0.91; 95% CI, 0.40–2.04), and pregnancy rate (RR, 0.79; 95% CI, 0.58–1.08).

Conclusion

The percentage of mature (MII) oocytes can be increased by prolonging the interval between hCG priming and oocyte retrieval. The prolonged interval could not increase the fertilization rate, implantation rate, and pregnancy rate. Although there was evidence to confirm the results, they still need to be confirmed by large-sample, multicenter, randomized controlled trials. The time interval dependent mechanisms responsible for ART performance need to be elucidated.

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Abbreviations

ART:

Assisted reproductive technology

ATP:

Adenosine triphosphate

CC:

Clomiphene citrate

COH:

Controlled ovarian hyperstimulation

ET:

Embryo transfer

FSH:

Follicle-stimulating hormone

GnRH-a:

Gonadotropic hormone releasing hormone analogue

hCG:

Human chorionic gonadotropin

hMG:

Human menopausal gonadotropin

ICSI:

Intracytoplasmic sperm injection

IGF:

Insulin-like growth factor

IL:

Interleukin

IM:

Intramuscular injection

IUI:

Intrauterine insemination

IVF:

In vitro fertilization

IVM:

In vitro maturation

LH:

Luteinizing hormone

LI:

Long interval

MII:

Metaphase II

NA:

Not available

RCT:

Randomized controlled trial

RevMan:

Review Manager

RR:

Risk ratio

SI:

Short interval

TUS:

Transvaginal ultrasound

VEGF:

Vascular endothelial growth factor

2PN:

Two-pronuclear

95% CI:

95% confidence interval

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Acknowledgments

The authors would like to thank Jin-Hui Tian, Bin Ma, Lei Jiang, Wen-Qin Jia, Kang Yi, and Lun Li (Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China) for advice on conducting the meta-analysis and writing the article.

Conflicts of interest statement

The authors declared no conflicts of interest related to this study.

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Authors and Affiliations

  1. The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China

    Wei Wang, Xue-Hong Zhang, Wei-Hua Wang, Li-Hui Zhao & Shi-Long Xue

  2. The Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China

    Ya-Li Liu & Ke-Hu Yang

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  1. Wei Wang
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Correspondence to Xue-Hong Zhang or Wei-Hua Wang.

Additional information

Capsule In ART treatment cycles, the chances to achieve a pregnancy are critically dependent on the retrieval of a suitable number of high quality oocytes and embryos. Angiotensin II, vascular endothelial growth factor (VEGF), interleukin I (IL-1), IL-6, IL-8, angiopoietin, insulin-like growth factor (IGF), basic fibroblast growth factor (bFGF), and endothelin levels appear able to identify women candidate for an ART treatment from whom a suitable number of high quality oocytes may be retrieved.

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Wang, W., Zhang, XH., Wang, WH. et al. The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis. J Assist Reprod Genet 28, 901–910 (2011). https://doi.org/10.1007/s10815-011-9613-x

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  • DOI: https://doi.org/10.1007/s10815-011-9613-x

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