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CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women

  • GENETICS
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The aim of the study was to evaluate the association of CYP1A1 and CYP1B1 polymorphisms with uterine leiomyoma in Chinese women.

Methods

We investigated 100 women with clinically diagnosed uterine leiomyoma and 110 healthy normal subjects from Chinese women. The genetic distribution of two CYP1A1 polymorphisms at MspI, Ile462Val and four CYP1B1 polymorphisms at Arg48Gly, Ala119Ser, Leu432Val, Asp449Asp were analyzed by polymerase chain reaction–restriction fragment length polymorphism and DNA sequencing method.

Results

All the SNPs showed polymorphisms in Chinese women. The genotype A/G and the allele G on Ile462Val was significantly different between uterine leiomyoma patients and controls (P < 0.05).

Conclusion

These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.

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Acknowledgments

This work has been supported by Neijiang First People’s Hospital.

Author information

Authors and Affiliations

  1. Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China

    Yi Ye, Xiao Cheng, Hai-Bo Luo, Ying-Bi Li & Yi-Ping Hou

  2. Institute of Forensic Medicine, Zunyi Medical College, Zunyi, 563003, Guizhou, China

    Li Liu

Authors
  1. Yi Ye
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  2. Xiao Cheng
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  3. Hai-Bo Luo
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  4. Li Liu
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Corresponding author

Correspondence to Yi-Ping Hou.

Additional information

Capsule This is the first report that demonstrates the polymorphism at Ile462Val of CYP1A1 to be associated with uterine leiomyoma in Chinese women.

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Ye, Y., Cheng, X., Luo, HB. et al. CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women. J Assist Reprod Genet 25, 389–394 (2008). https://doi.org/10.1007/s10815-008-9246-x

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  • DOI: https://doi.org/10.1007/s10815-008-9246-x

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