Abstract
Purpose: To investigate the effects of short-term low-dose aspirin and/or steroid use on implantation and pregnancy rates in nonselected intracytoplasmic sperm injection (ICSI) cycles.
Methods: Two-hundred patients undergoing ICSI for their first cycle were enrolled in this study. Participants were then randomized into four groups on the embryo transfer day. Aspirin (100 mg/day) in group A, prednisolone (10 mg/day) in group B, aspirin along with prednisolone in group C were given while placebo was administrated to group D.
Result: There were no statistically significant differences recorded in the demographic, ovulation induction cycle characteristics between groups. Mean transferred embryo number and mean top quality embryo number were similar among study groups. There were no statistical differences in implantation and pregnancy rates between study groups.
Conclusion: Administration of low-dose aspirin and prednisolone alone or concomitant as a standard treatment have no positive effects on implantation and/or pregnancy rates.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Chiaffarino F, Parazzini F, Paladini D, Acaia B, Ossola W, Marozio L, Facchinetti F, De Giudice A: A small randomised trial of low-dose aspirin in women at high risk of pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 2004;112(2):142–144
Wada I, Hsu C, Williams G, Macnamee M, Brinsden P: The benefits of low- dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod 1994;9(10):1954–1957
Sher G, Feinman M, Zouves C, Kuttner G, Massarani G, Salem R, Mater W, Chong P: High fecundity rates following in-vitro fertilization and embryo transfer in antiphospholipid antibody seropositive women treated with heparin and aspirin. Hum Reprod 1994;9:2278–2283
Hasegawa I, Yamanoto Y, Suzuki M, Murakawa H, Kurabayashi T, Takakuwa K, Tanaka K: Prednisolone plus low-dose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization. Fertil Steril 1998;7:1044–1048
Cohen J, Malter H, Elsner C, Kort H, Massey J, Mayer M: Immunusupression supports implantation of zona pellucida dissected human embryos. Fertil Steril 1990;53:662–665
Testart J, Gauther A: The action of anti-inflammatory drugs on the fertility of female rats with intrauterine contraceptive devices. J Reprod Fertil 1991;63:257–261
Weckstein L, Jocobson A, Galen D, Hampton R, Hamel J: Low dose aspirin for oocyte donation recipients with a thin endometrium: Prospective, randomized study. Fertil Steril 1997;68:927–930
Kuttch WH, Yetman DL, Chantilis SJ, Crain J: Effect of anti-phospholipid antibodies in women undergoing in-vitro fertilization: Role of heparin and aspirin. Hum Reprod 1997;12:1171–1175
Rubinstein M, Marazi A, Polak E: Lowe-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: A prospective, randomized, double-blind placebo-controlled assay. Fertil Steril 1990;71:825–829
Hurst BS, Bhojwani JT, Marshburn PB, Papadakis MA, Loeb TA, Matthews ML: Low-dose aspirin does not improve ovarian stimulation, endometrial response, or pregnancy rates for in vitro fertilization. J Exp Clin Assist Reprod 2005;2:8
Urman B, Mercan R, Alataş C, Balaban B, Işıklar A, Nuhoğlu A: A low-dose aspirin does not increase implantation rates in patients undergoing ICSI: A prospective randomized study. J Assist Reprod Genet 2000;17(10):586–590
Waldenstrom U, Hellberg D, Nilsson S: Low-dose aspirin in a short regimen as standard treatment in in vitro fertilization: A randomized, prospective study. Fertil Steril 2004;81(6):1560–1564
Malathy P, Cheng H, Dey S: Production of leukotrienes and prostaglandins in the rat uterus during preimplantation period. Prostaglandins 1986;32:602–614
Duc-Goiran P, Mignot T, Bourgeois C, Ferre F: Embryo–maternal interactions at the implantation site: A delicate equilibrium. Eur J Obstet Gynecol Reprod Biol 1999;83:85–100
Feinberg F, Kilman J, Lockwood J: Is oncofetal fibronectin a trophoblast glue for human implantation? Am J Pathol 1991;188:537–543
Wegman TG, Lin H, Guilbert I, Mossman R: Bidirectional cytokine interactions in the maternal–fetal relationships: Is successful pregnancy a Th 2 phenomenon? Immunol Today 1993;14:353–356
Polak F, Blanco L, Lancuba S, Asch R: Improvement of clinical pregnancy rate and implantation rate of in vitro fertilization–embryo transfer patients using methylprednisolone. Hum Reprod 1993;8:393–395
Ubaldi F, Rienzi L, Ferroro S, Anniballo R, Iacobelli M,Cobellis L, Greco E: Low dose prednisolon administration in routine ICSI patients does not improve pregnancy and implantations. Hum Reprod 2002;17(6):1544–1547
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Duvan, C.I., Ozmen, B., Satıroglu, H. et al. Does addition of low-dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? A randomized, prospective, placebo-controlled study. J Assist Reprod Genet 23, 15–21 (2006). https://doi.org/10.1007/s10815-005-9003-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10815-005-9003-3