Skip to main content
Log in

Dysregulation in Children and Adolescents Presenting to a Multidisciplinary Autism Clinic

  • Original Paper
  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

Abstract

Research indicates that children with autism spectrum disorder (ASD) frequently exhibit dysregulation, which refers to poorly coordinated affective, behavioral, and cognitive responses to a given situation. We examined the characteristics of dysregulation in children presenting to a multidisciplinary ASD clinic for an ASD diagnostic evaluation. Sixty percent of children presenting for an ASD evaluation exhibited dysregulation. Dysregulation prevalence was higher in children without ASD versus with ASD (69% versus 56%). Severe dysregulation was higher in children without ASD (29% versus 16%). Both groups with severe dysregulation were equally likely to be taking psychiatric medications, however, children with ASD were less likely to be receiving therapy. These findings highlight the importance of implementing dysregulation screening and treatment protocols in ASD centers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • Achenbach, T. M., & Rescorla, L. A. (2000). Manual for the ASEBA school-age forms & profiles. University of Vermont, Research Center for Children, Youth, & Families.

    Google Scholar 

  • Althoff, R. R., Ayer, L. A., Rettew, D. C., & Hudziak, J. J. (2010a). Assessment of dysregulated children using the child behavior checklist: A receiver operating characteristic curve analysis. Psychological Assessment, 22(3), 609–617. https://doi.org/10.1037/a0019699

    Article  PubMed  PubMed Central  Google Scholar 

  • Althoff, R. R., Verhulst, F. C., Rettew, D. C., Hudziak, J. J., & van der Ende, J. (2010b). Adult outcomes of childhood dysregulation: A 14-year follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry, 49(11), 1105–1116. https://doi.org/10.1016/j.jaac.2010.08.006

    Article  PubMed  PubMed Central  Google Scholar 

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders. (5th ed.). American Psychiatric Association.

    Book  Google Scholar 

  • Ayer, L., Althoff, R., Ivanova, M., Rettew, D., Waxler, E., Sulman, J., & Hudziak, J. (2009). Child behavior checklist juvenile bipolar disorder (CBCL-JBD) and CBCL posttraumatic stress problems (CBCL-PTSP) scales are measures of a single dysregulatory syndrome. Journal of Child Psychology and Psychiatry, 50(10), 1291–1300. https://doi.org/10.1111/j.1469-7610.2009.02089.x

    Article  PubMed  Google Scholar 

  • Azad, G. F., Singh, V., Kalb, L., Pinkett-Davis, M., & Landa, R. (2019). Child and family characteristics that predict autism spectrum disorder specialty clinic appointment attendance and alignment with providers. Journal of Autism and Developmental Disorders, 49(8), 3060–3072. https://doi.org/10.1007/s10803-019-04027-8

    Article  PubMed  Google Scholar 

  • Beck, K. B., Conner, C. M., White, S. W., & Mazefsky, C. A. (2020). Mindfulness “Here and now”: Strategies for helping adolescents with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 59(10), 1125–1127. https://doi.org/10.1016/j.jaac.2020.07.004

    Article  PubMed  Google Scholar 

  • Biederman, J., Petty, C. R., Monuteaux, M. C., Evans, M., Parcell, T., Faraone, S. V., & Wozniak, J. (2009). The child behavior checklist-pediatric bipolar disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: A longitudinal analysis. The Journal of Clinical Psychiatry, 70(5), 732–740. https://doi.org/10.4088/JCP.08m04821

    Article  PubMed  PubMed Central  Google Scholar 

  • Brookman-Frazee, L., Drahota, A., Stadnick, N., & Palinkas, L. A. (2012). Therapist perspectives on community mental health services for children with autism spectrum disorders. Administration and Policy in Mental Health, 39(5), 365–373. https://doi.org/10.1007/s10488-011-0355-y

    Article  PubMed  PubMed Central  Google Scholar 

  • Camm-Crosbie, L., Bradley, L., Shaw, R., Baron-Cohen, S., & Cassidy, S. (2019). “People like me don’t get support”: Autistic adults’ experiences of support and treatment for mental health difficulties, self-injury and suicidality. Autism, 23(6), 1431–1441. https://doi.org/10.1177/1362361318816053

    Article  PubMed  Google Scholar 

  • Conner, C. M., Golt, J., Shaffer, R., Righi, G., Siegel, M., & Mazefsky, C. A. (2021). Emotion dysregulation is substantially elevated in autism compared to the general population: Impact on psychiatric services. Autism Research, 14(169), 181. https://doi.org/10.1002/aur.2450

    Article  Google Scholar 

  • Crane, L., Adams, F., Harper, G., Welch, J., & Pellicano, E. (2019). “Something needs to change”: Mental health experiences of young autistic adults in England. Autism, 23(2), 477–493. https://doi.org/10.1177/1362361318757048

    Article  PubMed  Google Scholar 

  • Gotham, K., Pickles, A., & Lord, C. (2009). Standardizing ADOS scores for a measure of severity in autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(5), 693–705. https://doi.org/10.1007/s10803-008-0674-3

    Article  PubMed  Google Scholar 

  • Grzadzinski, R., Di Martino, A., Brady, E., Mairena, M. A., O’Neale, M., Petkova, E., Lord, C., & Castellanos, F. X. (2011). Examining autistic traits in children with ADHD: Does the autism spectrum extend to ADHD? Journal of Autism and Developmental Disorders, 41(9), 1178–1191. https://doi.org/10.1007/s10803-010-1135-3

    Article  PubMed  PubMed Central  Google Scholar 

  • Holtmann, M., Buchmann, A. F., Esser, G., Schmidt, M. H., Banaschewski, T., & Laucht, M. (2011). The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment: A longitudinal analysis. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 52(2), 139–147. https://doi.org/10.1111/j.1469-7610.2010.02309.x

    Article  PubMed  Google Scholar 

  • Joshi, G., Faraone, S. V., Wozniak, J., Petty, C., Fried, R., Galdo, M., Furtak, S. L., McDermott, K., Epstien, C., Walker, R., Caron, A., Feinberg, L., & Biederman, J. (2014). Examining the clinical correlates of autism spectrum disorder in youth by ascertainment source. Journal of Autism and Developmental Disorders, 44(9), 2117–2126. https://doi.org/10.1007/s10803-014-2063-4

    Article  PubMed  PubMed Central  Google Scholar 

  • Joshi, G., Wozniak, J., Fitzgerald, M., Faraone, S., Fried, R., Galdo, M., Furtak, S. L., Conroy, K., Kilcullen, J. R., Belser, A., & Biederman, J. (2018). High risk for severe emotional dysregulation in psychiatrically referred youth with autism spectrum disorder: A controlled study. Journal of Autism and Developmental Disorders, 48(9), 3101–3115. https://doi.org/10.1007/s10803-018-3542-9

    Article  PubMed  Google Scholar 

  • Jucksch, V., Salbach-Andrae, H., Lenz, K., Goth, K., Döpfner, M., Poustka, F., Freitag, C. M., Lehmkuhl, G., Lehmkuhl, U., & Holtmann, M. (2011). Severe affective and behavioural dysregulation is associated with significant psychosocial adversity and impairment. Journal of Child Psychology and Psychiatry, 52(6), 686–695

    Article  Google Scholar 

  • Kalb, L. G., Stuart, E. A., Mandell, D. S., Olfson, M., & Vasa, R. A. (2017). Management of mental health crises among youths with and without autism spectrum disorder: A national survey of child psychiatrists. Psychiatric Services (washington, d.c.), 68(10), 1039–1045. https://doi.org/10.1176/appi.ps.201600332

    Article  Google Scholar 

  • Kalb, L. G., Hagopian, L. P., Gross, A. L., & Vasa, R. A. (2018). Psychometric characteristics of the mental health crisis assessment scale in youth with autism spectrum disorder. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 59(1), 48–56. https://doi.org/10.1111/jcpp.12748

    Article  PubMed  Google Scholar 

  • Kalb, L., Jacobson, L., Zisman, C., Mahone, E., Landa, R., Azad, G., Menon, D., Singh, V., Zabel, A., & Pritchard, A. (2019). Interest in research participation among caregivers of children with neurodevelopmental disorders. Journal of Autism and Developmental Disorders, 49(9), 3786–3797. https://doi.org/10.1007/s10803-019-04088-9

    Article  PubMed  PubMed Central  Google Scholar 

  • Kanne, S. M., & Bishop, S. L. (2020). Editorial Perspective: The autism waitlist crisis and remembering what families need. Journal of Child Psychology and Psychiatry, and Allied Disciplines,. https://doi.org/10.1111/jcpp.13254

    Article  Google Scholar 

  • Keefer, A., Singh, V., Kalb, L. G., Mazefsky, C. A., & Vasa, R. A. (2020). Investigating the factor structure of the child behavior checklist dysregulation profile in children and adolescents with autism spectrum disorder. Autism Research, 13(3), 436–443. https://doi.org/10.1002/aur.2233

    Article  PubMed  Google Scholar 

  • Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism diagnostic observation schedule. (2nd ed.). Western Psychological Services.

    Google Scholar 

  • Maddox, B. B., Kang-Yi, C. D., Brodkin, E. S., & Mandell, D. S. (2018). Treatment utilization by adults with autism and co-occurring anxiety or depression. Research in Autism Spectrum Disorders, 51, 32–37. https://doi.org/10.1016/j.rasd.2018.03.009

    Article  PubMed  PubMed Central  Google Scholar 

  • Magyar, C. I., & Pandolfi, V. (2017). Utility of the CBCL DSM-oriented scales in assessing emotional disorders in youth with autism. Research in Autism Spectrum Disorders, 37, 11–20. https://doi.org/10.1016/j.rasd.2017.01.009

    Article  PubMed  PubMed Central  Google Scholar 

  • Marrus, N., Veenstra-Vanderweele, J., Hellings, J. A., Stigler, K. A., Szymanski, L., King, B. H., Carlisle, L. L., Cook, E. H., Jr., American Academy of Child Adolescent Psychiatry (AACAP) Autism and Intellectual Disability Committee, & Pruett, J. R., Jr. (2014). Training of child and adolescent psychiatry fellows in autism and intellectual disability. Autism, 18(4), 471–475. https://doi.org/10.1177/1362361313477247

    Article  PubMed  Google Scholar 

  • Masi, G., Pisano, S., Milone, A., & Muratori, P. (2015). Child behavior checklist dysregulation profile in children with disruptive behavior disorders: A longitudinal study. Journal of Affective Disorders, 186, 249–253. https://doi.org/10.1016/j.jad.2015.05.069

    Article  PubMed  Google Scholar 

  • Mazefsky, C. A., Oswald, D. P., Day, T. N., Eack, S. M., Minshew, N. J., & Lainhart, J. E. (2012). ASD, a psychiatric disorder, or both? Psychiatric diagnoses in adolescents with high-functioning ASD. Journal of Clinical Child and Adolescent, 41(4), 516–523. https://doi.org/10.1080/15374416.2012.686102

    Article  Google Scholar 

  • Mazefsky, C. A., Yu, L., White, S. W., Siegel, M., & Pilkonis, P. A. (2018). The emotion dysregulation inventory: Psychometric properties and item response theory calibration in an autism spectrum disorder sample. Autism Research, 11(6), 928–941. https://doi.org/10.1002/aur.1947

    Article  PubMed  PubMed Central  Google Scholar 

  • McCracken, J. T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., Arnold, L. E., Lindsay, R., Nash, P., Hollway, J., McDougle, C. J., Posey, D., Swiezy, N., Kohn, A., Scahill, L., Martin, A., Koenig, K., Volkmar, F., Carroll, D., … Research Units on Pediatric Psychopharmacology Autism Network. (2002). Risperidone in children with autism and serious behavioral problems. The New England Journal of Medicine, 347(5), 314–321. https://doi.org/10.1056/NEJMoa013171

    Article  PubMed  Google Scholar 

  • Medeiros, K., Mazurek, M. O., & Kanne, S. (2017). Investigating the factor structure of the child behavior checklist in a large sample of children with autism spectrum disorder. Research in Autism Spectrum Disorders, 40, 24–40. https://doi.org/10.1016/j.rasd.2017.06.001

    Article  Google Scholar 

  • Meyer, S. E., Carlson, G. A., Youngstrom, E., Ronsaville, D. S., Martinez, P. E., Gold, P. W., Hakak, R., & Radke-Yarrow, M. (2009). Long-term outcomes of youth who manifested the CBCL-pediatric bipolar disorder phenotype during childhood and/or adolescence. Journal of Affective Disorders, 113(3), 227–235. https://doi.org/10.1016/j.jad.2008.05.024

    Article  PubMed  Google Scholar 

  • Research Units on Pediatric Psychopharmacology Autism Network. (2005). Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Archives of General Psychiatry, 62(11), 1266–1274. https://doi.org/10.1001/archpsyc.62.11.1266

    Article  Google Scholar 

  • Settipani, C. A., Puleo, C. M., Conner, B. T., & Kendall, P. C. (2012). Characteristics and anxiety symptom presentation associated with autism spectrum traits in youth with anxiety disorders. Journal of Anxiety Disorders, 26(3), 459–467. https://doi.org/10.1016/j.janxdis.2012.01.010

    Article  PubMed  PubMed Central  Google Scholar 

  • StataCorp. (2017). Stata statistical software (release 15). StataCorp LLC.

    Google Scholar 

  • Vasa, R. A., Hagopian, L., & Kalb, L. G. (2020). Investigating mental health crisis in youth with autism spectrum disorder. Autism Research, 13(1), 112–121. https://doi.org/10.1002/aur.2224

    Article  PubMed  Google Scholar 

  • White, S. W., Conner, C. M., Beck, K. B., & Mazefsky, C. A. (2020). Clinical update: The implementation of evidence-based emotion regulation treatment for clients with autism. Evidence-Based Practice in Child and Adolescent Mental Health. https://doi.org/10.1080/23794925.2020.1796551

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Study conception and design (R.V., A.K.), data collection (V.S.), statistical analyses (V.S.), interpretation of results (all authors), draft manuscript (R.V.), critical review of the manuscript (all authors).

Corresponding author

Correspondence to Roma A. Vasa.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vasa, R.A., Singh, V., McDonald, R.G. et al. Dysregulation in Children and Adolescents Presenting to a Multidisciplinary Autism Clinic. J Autism Dev Disord 52, 1762–1770 (2022). https://doi.org/10.1007/s10803-021-05056-y

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10803-021-05056-y

Keywords

Navigation