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Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood

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Abstract

Exposure to prenatal stress increases offspring risk for long-term neurobehavioral impairments and psychopathology, such as Attention Deficit Hyperactivity Disorder (ADHD). Epigenetic regulation of glucocorticoid pathway genes may be a potential underlying mechanism by which maternal conditions ‘program’ the fetal brain for downstream vulnerabilities. The present study aims to investigate whether mRNA expression of glucocorticoid pathway genes in the placenta predict offspring negative affect during early childhood (between 6 and 24 months). Participants include 318 mother-child dyads participating in a longitudinal birth cohort study. Placental mRNA expression of glucocorticoid pathway genes (HSD11B1, HSD11B2, NR3C1, NCOR2) were profiled and negative affect traits of the offspring were measured at 6, 12, 18, and 24 months. HSD11B1 mRNA expression significantly predicted negative affect (β = −.09, SE = .04; p = .036), and Distress to Limitations trajectories (β = −.13, SE = .06; p = .016). NCOR2 mRNA expression significantly predicted Distress to Limitations (β = .43, SE = .21; p = .047), and marginally predicted Sadness trajectories (β = .39, SE = .21; p = .068). HSD11B2 and NR3C1 did not predict trajectories of Negative Affect or subscale scores. Infant negative affect traits were assessed via maternal self-report, and deviated from linearity across follow-up. mRNA expression of glucocorticoid pathway genes in the placenta may be a potentially novel tool for early identification of infants at greater risk for elevated negative affect. Further study is needed to validate the utility of mRNA expression of glucocorticoid pathway genes in the placenta.

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Funding

Collection of this data was supported by the grants K01MH080062, K01MH080062S and R01MH102729 from the National Institutes of Mental Health (NIMH), and PSC-CUNY Research Enhancement Grant.

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Authors and Affiliations

  1. CUNY Graduate School of Public Health and Health Policy, Department of Epidemiology and Biostatistics, 55 W 125th St., New York, NY, 10027, USA

    J. Finik

  2. CUNY Queens College, Department of Psychology, 65-30 Kissena Blvd, Flushing, NY, 11367, USA

    J. Finik, J. Buthmann, W. Zhang, K. Go & Y. Nomura

  3. CUNY Graduate Center, Department of Psychology, 365 5th Avenue, New York, NY, 10016, USA

    J. Buthmann & Y. Nomura

  4. New Jersey City University, Department of Psychology, 2039 John Fitzgerald Kennedy Blvd, Jersey City, NJ, 07305, USA

    W. Zhang

  5. Nova Southeastern University, Dr. Kiran C. Patel College of Osteopathic Medicine, 3301 College Avenue, Fort Lauderdale, FL, 33314, USA

    K. Go

  6. CUNY Advanced Science Research Center, Graduate Center, 85 St Nicholas Terrace, New York, NY, 10031, USA

    Y. Nomura

  7. Icahn School of Medicine at Mount Sinai, Department of Psychiatry, 1 Gustave Levy Pl, New York, NY, 10029, USA

    Y. Nomura

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  1. J. Finik
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Finik, J., Buthmann, J., Zhang, W. et al. Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood. J Abnorm Child Psychol 48, 783–795 (2020). https://doi.org/10.1007/s10802-020-00632-9

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