Abstract
A sensitive, simple and rapid square-wave adsorptive stripping voltammetric method was developed and validated for the determination of candesartan cilexetil in pharmaceutical formulations. The proposed method was based on electrochemical reduction of candesartan cilexetil at a hanging mercury drop electrode in phosphate buffer at pH 5.0. A well-defined reduction peak was observed at −1340 mV with 30 s of accumulation time and −1100 mV of accumulation potential. Under these optimized conditions, the square-wave adsorptive stripping voltammetric peak current showed a linear correlation on drug concentration over the range of 0.25–1.34 µg mL−1 with a correlation coefficient of 0.9986 for the proposed method. The detection and quantitation limits for this method were 1 × 10−2 and 2.5 × 10−1 µg mL−1, respectively. The results obtained for intra-day and inter-day precision (as RSD%) were between 1.10 and 3.90%. This method was applied successfully for the determination of candesartan cilexetil in its tablet dosage forms with mean recoveries of 101.13 ± 0.78% with RSD of 2.06% for 8 mg tablet and 99.84 ± 0.89% with RSD of 2.36% for 16 mg tablet. The results obtained from the developed square-wave adsorptive stripping voltammetric method were compared with those obtained by the analytical method reported in the literature.
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Süslü, İ., Özaltın, N. & Altınöz, S. Square-wave adsorptive stripping voltammetric determination of candesartan cilexetil in pharmaceutical formulations. J Appl Electrochem 39, 1535–1543 (2009). https://doi.org/10.1007/s10800-009-9836-z
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DOI: https://doi.org/10.1007/s10800-009-9836-z