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Recent indications of endothelial keratoplasty at a tertiary eye care center in South India

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Abstract

Purpose

To describe the patient demographics and recent clinical indications of endothelial keratoplasty (EK) in patients presenting to a tertiary eye care center in India.

Methods

This cross-sectional hospital-based study included 2,182 patients who underwent EK between Jan 2016 and Dec 2019 (4 years period). The data were collected using an electronic medical record system.

Results

Overall, 2,632 eyes of 2,182 patients underwent EK during the study period. Median age was 62 (IQR: 48–70) years and adults (94.45%) comprised most of the cohort. More commonly, the patients were male (55.59%) and from the higher socioeconomic strata (67.51%). The corneal signs included corneal edema (70.93%), corneal scarring (29.60%), corneal vascularization (16%) and guttae (12.88%). The major indications of EK were post-cataract surgery corneal edema in 1331 (50.57%) patients, endothelial dystrophy in 537 (20.4%) patients, failed graft in 535 (20.33%) patients causing a vision impairment of > 20/400–20/1200 in about a half (45.55%) of the patients. Descemet stripping endothelial keratoplasty (DSEK) and Descemet membrane endothelial keratoplasty (DMEK) were performed in 2075 (78.84%) and 557(21.16%) patients, respectively.

Conclusion

EK is commonly performed during the sixth decade of life and in males. The most performed procedure is DSEK. The commonest indication was post-cataract surgery corneal edema.

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References

  1. Boynton GE, Woodward MA (2015) Evolving techniques in corneal transplantation. Curr Surg Rep. https://doi.org/10.1007/s40137-014-0079-5

    Article  PubMed  PubMed Central  Google Scholar 

  2. Gorovoy MS (2006) Descemet-stripping automated endothelial keratoplasty. Cornea 25(8):886–889

    Article  Google Scholar 

  3. Melles GRJ (2006) Posterior lamellar keratoplasty: DLEK to DSEK to DMEK. Cornea 25:879–881

    Article  Google Scholar 

  4. Veldman PB, Terry MA, Straiko MD (2014) Evolving indications for Descemet’s stripping automated endothelial keratoplasty. Curr Opin Ophthalmol 25(4):306–311

    Article  Google Scholar 

  5. Mohamed A, Chaurasia S, Murthy SI, Ramappa M, Vaddavalli PK, Taneja M, Garg P, Chinta S, Basu S, Rathi VM, Sangwan VS (2014) Endothelial keratoplasty: a review of indications at a tertiary eye care centre in South India. Asia Pac J Ophthalmol (Phila) 3(4):207–210

    Article  Google Scholar 

  6. Rao GN, Khanna RC, Athota SM, Rajshekar V, Rani PK (2012) Integrated model of primary and secondary eye care for underserved rural areas: the L V Prasad eye institute experience. Indian J Ophthalmol 60:396–400

    Article  Google Scholar 

  7. Das AV, Kammari P, Vadapalli R, Basu S (2020) Big data and the eyeSmart electronic medical record system - An 8-year experience from a three-tier eye care network in India. Indian J Ophthalmol 68(3):427–432

    Article  Google Scholar 

  8. Das AV, Podila S, Prashanthi GS, Basu S (2020) Clinical profile of pterygium in patients seeking eye care in India: electronic medical records-driven big data analytics report III. Int Ophthalmol 40(6):1553–1563

    Article  Google Scholar 

  9. World Health Organization. (2008). Change the Definition of Blindness [PDF file]. Retrieved from https://www.who.int/blindness/Change%20the%20Definition%20of%20Blindness.pdf

  10. Matthaei M, Sandhaeger H, Hermel M, Adler W, Jun AS, Cursiefen C, Heindl LM et al (2017) Changing indications in penetrating keratoplasty: a systematic review of 34 years of global reporting. Transplantation 101:1387–1399

    Article  Google Scholar 

  11. Zhang AQ, Rubenstein D, Price AJ, Côté E, Levitt M, Sharpen L, Slomovic A (2013) Evolving surgical techniques of and indications for corneal transplantation in Ontario: 2000–2012. Can J Ophthalmol 48(3):153–159

    Article  Google Scholar 

  12. Park CY, Lee JK, Gore PK, Lim CY, Chuck RS (2015) Keratoplasty in the United States: A 10-Year Review from 2005 through 2014. Ophthalmology 122(12):2432–2442

    Article  Google Scholar 

  13. Frigo AC, Fasolo A, Capuzzo C, Fornea M, Bellucci R, Busin M, Marchini G, Pedrotti E, Ponzin D, CORTES Study Group (2015) Corneal transplantation activity over 7 years: changing trends for indications, patient demographics and surgical techniques from the Corneal Transplant Epidemiological Study (CORTES). Transplant Proc 47(2):528–35

    Article  CAS  Google Scholar 

  14. Peraza-Nieves J, Baydoun L, Dapena I, Ilyas A, Frank LE, Luceri S, Ham L, Oellerich S, Melles GRJ (2017) Two-year clinical outcome of 500 consecutive cases undergoing descemet membrane endothelial keratoplasty. Cornea 36(6):655–660

    Article  Google Scholar 

  15. Flockerzi E, Maier P, Böhringer D, Reinshagen H, Kruse F, Cursiefen C, Reinhard T, Geerling G, Torun N, Seitz B (2018) All German keratoplasty registry contributors. trends in corneal transplantation from, 2001 to 2016 in Germany: a report of the DOG-Section Cornea and its keratoplasty registry. Am J Ophthalmol 2018(188):91–98

    Article  Google Scholar 

  16. Röck T, Bartz-Schmidt KU, Röck D (2018) Trends in corneal transplantation at the University Eye Hospital in Tübingen, Germany over the last 12 years: 2004–2015. PLoS One 13(6):e0198793

    Article  CAS  Google Scholar 

  17. Basak SK, Basak S, Gajendragadkar N, Ghatak M (2020) Overall clinical outcomes of descemet membrane endothelial keratoplasty in 600 consecutive eyes: a large retrospective case series. Indian J Ophthalmol 68(6):1044–1053

    Article  Google Scholar 

  18. Chaurasia S, Mohamed A, Garg P, Balasubramanian D, Rao GN (2020) Thirty years of eye bank experience at a single center in India. Int Ophthalmol 40(1):81–88

    Article  Google Scholar 

  19. Das AV, Chaurasia S (2020) Clinical Profile and Demographic Distribution of Corneal Dystrophies in India: a Study of 4198 Patients. Cornea 40(5):548–553

    Article  Google Scholar 

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Acknowledgements

The authors wish to acknowledge the support of the Department of eyeSmart EMR & AEye team especially Mr. Ranganath Vadapalli and Mr. Mohammad Pasha and team of Ramayamma International Eye Bank (K. Hariharan, K. Srinivas and G. Srinivas).

Funding

Hyderabad Eye Research Foundation, Hyderabad, India.

Author information

Authors and Affiliations

  1. Department of eyeSmart EMR & AEye, L V Prasad Eye Institute, Hyderabad, India

    Anthony Vipin Das

  2. Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India

    Ashik Mohamed

  3. The Cornea Institute, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, , Hyderabad, 500034, Telangana, India

    Sunita Chaurasia

  4. Ramayamma International Eye Bank, L V Prasad Eye Institute, Hyderabad, India

    Sunita Chaurasia

Authors
  1. Anthony Vipin Das
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  2. Ashik Mohamed
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The corresponding author states that authorship credit of this manuscript was based on 1) substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; 2) drafting the article or revising it critically for important intellectual content; and 3) final approval of the version to be published. All listed authors met conditions 1, 2 and 3. All persons designated as authors qualify for authorship, and all those who qualify are listed. Each author has participated sufficiently in the work to take public responsibility for appropriate portions of the content.

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Correspondence to Sunita Chaurasia.

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Das, A.V., Mohamed, A. & Chaurasia, S. Recent indications of endothelial keratoplasty at a tertiary eye care center in South India. Int Ophthalmol 41, 3277–3285 (2021). https://doi.org/10.1007/s10792-021-01889-9

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  • DOI: https://doi.org/10.1007/s10792-021-01889-9

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