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Early changes in retinal microcirculation after uncomplicated cataract surgery using an active-fluidics system

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Abstract

Purpose

To evaluate the early changes in retinal microcirculation after uncomplicated cataract surgery using an active-fluidics system.

Materials and methods

Patients underwent uncomplicated cataract surgery for both eyes were enrolled. The two eyes of the patients were randomly assigned to two groups, the active-fluidics group and the gravity-fluidics group. One eye using an active-fluidics system, and the other using a gravity-fluidics system. Optical coherence tomography angiography (OCTA) was performed at 1 day, 7 days, 30 days, and 90 days after surgery.

Results

Fifty eyes (25 patients) were included in the final analysis. A significantly lower cumulative dissipated energy (CDE), estimated fluid usage (EFU), and total aspiration time (TAT) were observed in the active-fluidics group (all P<0.05). The superficial vessel density at parafoveal region increased at 7 days and 30 days after cataract surgery in the eyes of both the active-fluidics and gravity-fluidics groups, with the fluctuation in eyes of the gravity-fluidics group more significant. The vessel density of deep capillary plexus remained stable during the follow-up period. Significant changes of retinal thickness in macular region (fovea, parafovea) were observed in eyes of the gravity-fluidics group through the comparison of corresponding values at different time points (p = 0.008, 0.005). No significant change in retinal thickness was observed in eyes of the active-fluidics.

Conclusions

Retinal microcirculation and thickness were disturbed after cataract surgery using the gravity-fluidics infusion system. The active-fluidics system not only improved the surgical efficacy but also protected the retinal vasculature during cataract surgery.

Clinical trials registration: The study has been registered at www.clinicaltrials.gov with its clinical trial accession number of NCT0130500.

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Data availability

All data used to support the findings of this study were included within the article.

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Acknowledgements

This study was supported by the [Medical and Health Technology Program of Zhejiang Province #1] under the Grant [number2017KY494]; [Zhejiang Provincial Key Research and Development Program#2] under the Grant [number 2018C03012].

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Authors and Affiliations

  1. Eye Hospital of Wenzhou Medical University at hanghzou, 618 Fengqi east Road, Hangzhou, 310000, Zhejiang, China

    Yinying Zhao, Dandan Wang, Li Nie, Yuhong Yu, Rui Zou, Zhangliang Li, Mengxiang Xu & Yune Zhao

Authors
  1. Yinying Zhao
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  2. Dandan Wang
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  3. Li Nie
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  4. Yuhong Yu
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  5. Rui Zou
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  6. Zhangliang Li
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  7. Mengxiang Xu
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  8. Yune Zhao
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Contributions

YYZ., DDW., LN., YHY contributed to conducted the study and collected the data. YEZ., DDW were involved in reviewed the manuscript. YEZ., YYZ contributed to conceived and designed the experiments. RZ., ZLL., MXX were involved in analyzed the data. YYZ.,YEZ contributed to wrote the paper.

Corresponding author

Correspondence to Yune Zhao.

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Conflict of interest

The authors have no financial or proprietary interest in the materials herein

Ethical approval

The study was approved by the Research Review Board at Wenzhou Medical University.

Informed consent

All procedure and studies were conducted in accordance with the tenets of the Declaration of Helsinki, and written informed consent was obtained from all the patients.

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Zhao, Y., Wang, D., Nie, L. et al. Early changes in retinal microcirculation after uncomplicated cataract surgery using an active-fluidics system. Int Ophthalmol 41, 1605–1612 (2021). https://doi.org/10.1007/s10792-021-01694-4

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  • DOI: https://doi.org/10.1007/s10792-021-01694-4

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