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Further evidence of the association of latent Mycobacterium tuberculosis in Eales’ disease

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Abstract

Purpose

To find out association of Eales’ disease with Mycobacterium tuberculosis.

Methods

A retrospective study was done recruiting patients visiting the uvea clinic with diagnosis of Eales’ disease from 2015–2019. Seventy-nine eyes of 50 patients diagnosed as Eales’ disease underwent Mantoux test, QuantiFERON-TB Gold test, high resolution computed tomography (HRCT) of the chest and anterior chamber or vitreous tap for TB genome polymerase chain reaction(PCR).

Results

The study included 41 males and 9 females. The mean age of the patient was 35.62 ± 11.49 y. Out of 50 patients, 42% (n = 21) patients had unilateral involvement. Mantoux test was positive in 73% patients. QuantiFERON-TB Gold test was positive in 56% patients. HRCT chest was suggestive of pulmonary tuberculosis in 34% patients. Out of 6 patients, PCR from anterior chamber tap showed TB genome positive in 2 (33.3%) patients. Out of 9 patients, vitreous tap PCR was positive for TB genome in 2 (22.2%) patients.

Conclusions

Our study showed that one or more tests were positive for TB in Eales’ disease suggesting a pivotal role of TB as a primary etiology for this disease. We conclude that Eales’ disease is associated with Mycobacterium tuberculosis infection.

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Funding

Nil.

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Authors and Affiliations

  1. Department of Uvea, Medical and Vision Research Foundation, Sankara Nethralaya, No. 41 (old 18), College RoadTamil Nadu, Chennai, 600006, India

    Prasad Gupta & Jyotirmay Biswas

Authors
  1. Prasad Gupta
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  2. Jyotirmay Biswas
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Contributions

Dr Gupta P: Manuscript writing; Dr Biswas J: Inception of the idea.

Corresponding author

Correspondence to Prasad Gupta.

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Conflict of interest

The authors report no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Gupta, P., Biswas, J. Further evidence of the association of latent Mycobacterium tuberculosis in Eales’ disease. Int Ophthalmol 41, 901–906 (2021). https://doi.org/10.1007/s10792-020-01645-5

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  • DOI: https://doi.org/10.1007/s10792-020-01645-5

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