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Does functional assessment predict everyday visual functioning? Visual function testing and quality of life in mild/moderate age-related macular degeneration

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Abstract

Purpose

To prospectively assess correlations between self-reported vision-related quality of life (VR-QoL) and clinical functional assessments in mild/moderate age-related macular degeneration (AMD).

Methods

Cross-sectional analysis of 64 participants with bilateral mild/moderate AMD. Microperimetry (MP), flicker perimetry (FP), multifocal electroretinogram (mfERG) findings, best-corrected visual acuity (BCVA) and the National Eye Institute Visual-Function Questionnaire-25 (NEI VFQ-25) were assessed for correlation between clinical testing results and NEI VFQ-25 findings.

Results

MP findings in the better eye were weakly correlated with NEI VFQ-25 subscales for colour, general, near and distance vision (p < 0.05 and R2 < 0.3 for all). FP findings and mfERG response density were not correlated with any subscale, apart from mfERG ring 1 response density and general health (p < 0.05, R2 = 0.41). mfERG latency was weakly correlated with general vision in the better eye in rings 2 and 4 (p < 0.05, R2 < 0.2).

Conclusion

Functional assessment in mild/moderate AMD is at best, weakly correlated with patient-reported VR-QoL. Despite the growing awareness of the importance of VR-QoL outcomes in improving patient outcomes and satisfaction, surrogate markers of these outcomes remain elusive, and testing of VR-QoL in regular clinical settings remains difficult.

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Authors and Affiliations

  1. Save Sight Institute, The University of Sydney, Sydney, Australia

    Geoffrey K. Broadhead, John R. Grigg, Peter McCluskey, Kimberly Spooner & Andrew A. Chang

  2. Sydney Institute of Vision Science, Sydney, Australia

    Geoffrey K. Broadhead, Thomas Hong, Kimberly Spooner & Andrew A. Chang

  3. Sydney Retina Clinic & Day Surgery, Level 13, 187 Macquarie Street, Sydney, NSW, 2000, Australia

    Geoffrey K. Broadhead, Thomas Hong, Kimberly Spooner & Andrew A. Chang

  4. Sydney School of Public Health, The University of Sydney, Sydney, Australia

    Timothy E. Schlub

Authors
  1. Geoffrey K. Broadhead
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  2. Thomas Hong
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  3. John R. Grigg
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  4. Peter McCluskey
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  5. Timothy E. Schlub
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  6. Kimberly Spooner
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  7. Andrew A. Chang
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Corresponding author

Correspondence to Andrew A. Chang.

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Conflict of interest

No authors have any conflicts of interest to declare, and there was no funding associated with this study. One previous researcher associated with this study who had no participant contact, was previously required to withdraw his involvement from the study due to a conflict of interest.

Human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Broadhead, G.K., Hong, T., Grigg, J.R. et al. Does functional assessment predict everyday visual functioning? Visual function testing and quality of life in mild/moderate age-related macular degeneration. Int Ophthalmol 40, 3241–3249 (2020). https://doi.org/10.1007/s10792-020-01508-z

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  • DOI: https://doi.org/10.1007/s10792-020-01508-z

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