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Effects of topical autologous serum on the ocular surface in patients with toxic corneal epitheliopathy induced by anti-glaucoma drugs

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Abstract

Purpose

To investigate the effects of topical autologous serum application on the ocular surface in patients with toxic corneal epitheliopathy induced by anti-glaucoma drugs.

Methods

The patients who had corneal epitheliopathy because of preservative-containing anti-glaucoma eye drops were prospectively enrolled. The epitheliopathy was refractory to preservative-free artificial tear treatment. The patients topically applied 20% autologous serum to the eye eight times per day for 1 month. Baseline and one-month change in symptoms and signs were assessed by the Ocular Surface Disease Index (OSDI) questionnaire, tear film break-up time (TFBUT), Schirmer I values, corneoconjunctival staining scores, corneal sensitivity, InflammaDry® tear immunoassay, and tear cytokine profiles using a bead-based multiplex assay.

Results

A total of ten consecutive patients were enrolled between January and August 2018 and evaluated after one-month treatment with 20% autologous serum eye drops. Significant improvement was observed in symptoms (OSDI scores from 25.5 ± 20.9 to 10.5 ± 12.0; P = .039), TFBUT (from 3.1 ± 1.8 s to 5.4 ± 2.3 s; P = .025), corneoconjunctival staining scores (from 7.7 ± 1.8 to 1.8 ± 1.9 NEI scale; P = .005), corneal sensitivity (from 4.6 ± .9 cm to 5.8 ± .5 cm; P = .013), and metalloproteinase-9 levels (P = .013). There were no significant changes in Schirmer I values and tear cytokine levels on multiplex assays. Treatment-related side effects were not detected.

Conclusions

Topical instillation of 20% autologous serum is an effective treatment for toxic corneal epitheliopathy associated with anti-glaucoma eye drops.

Trial registration number

KCT0003827.

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Funding

This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2018R1A2B2004108).

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Authors and Affiliations

  1. Department of Ophthalmology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Chang Ho Yoon, Mee Kum Kim, Jin Wook Jeoung & Joo Youn Oh

  2. Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Chang Ho Yoon, Hyun Ju Lee, Mee Kum Kim & Joo Youn Oh

  3. Tissue Bank, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Hye Youn Park

  4. Department of Laboratory Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Hyungsuk Kim

Authors
  1. Chang Ho Yoon
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  2. Hyun Ju Lee
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  3. Hye Youn Park
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  4. Hyungsuk Kim
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  5. Mee Kum Kim
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  6. Jin Wook Jeoung
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  7. Joo Youn Oh
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Corresponding author

Correspondence to Joo Youn Oh.

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Conflict of interest

All authors have no conflict of interest.

Ethical approval

This study was approved by the Institutional Review Board of Seoul National University Hospital (No. 1705-086-855). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was retrospectively registered on Clinical Research Information Service (CRiS), Republic of Korea (Trial registration number: KCT0003827) on 19/04/2019. The first registration date was 11/04/2018.

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Informed consent was obtained from all individual participants included in the study.

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Yoon, C.H., Lee, H.J., Park, H.Y. et al. Effects of topical autologous serum on the ocular surface in patients with toxic corneal epitheliopathy induced by anti-glaucoma drugs. Int Ophthalmol 40, 547–552 (2020). https://doi.org/10.1007/s10792-019-01211-8

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  • DOI: https://doi.org/10.1007/s10792-019-01211-8

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