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Optic nerve head slope-based quantitative parameters for identifying open-angle glaucoma on SPECTRALIS OCT images

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Abstract

Purpose

To investigate monitoring slope-based features of the optic nerve head (ONH) cup as open-angle glaucoma (OAG) occurs.

Method

A dataset of 46 retrospective OCT cases was acquired from the SPECTRALIS Heidelberg Engineering OCT device. A set of five parameters, which are based on the ONH cup-incline, are measured on the OAG and normal subjects in the dataset. Then, three new ONH cup-shape indices were deduced. The ONH cup-incline parameters and ONH cup-shape indices are analyzed to estimate their clinical value.

Results

The statistical difference between measurements on normal and glaucoma eyes was remarkably significant for all of the analyzed parameters and indices (p value < 0.001).

Conclusions

The geometric shape of the ONH cup can be transferred to numerical parameters and indices. The proposed ONH cup-incline parameters and ONH cup-shape indices have shown suggestive clinical value to identify the development of OAG. As OAG appears, the top ONH cup-incline parameters decrease while the bottom ONH cup-incline parameters increase. The ONH cup-shape indices suggest capability to discriminate OAG from normal eyes.

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Acknowledgments

Authors would like to present their thanks and gratefulness to the medical staff in the ophthalmology clinic at the Specialty hospital in Amman, Jordan, for their kindness and cooperation to collect the research data.

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Authors and Affiliations

  1. Medical Imaging Department, Faculty of Allied Health Sciences, The Hashemite University, Zarqa, Jordan

    Abdel-Razzak M. Al-Hinnawi

  2. Biomedical Engineering Department, Faculty of Engineering, The Hashemite University, P.O. Box 150459, Zarqa, 13115, Jordan

    Bassam O. Al-Naami

  3. Ophthalmology Department, Faculty of Medicine, The Hashemite University, Zarqa, Jordan

    Motasem M. Al-Latayfeh

Authors
  1. Abdel-Razzak M. Al-Hinnawi
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  2. Bassam O. Al-Naami
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  3. Motasem M. Al-Latayfeh
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Corresponding author

Correspondence to Bassam O. Al-Naami.

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The authors declare that they have no conflict of interest.

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The subjects in this experiment are retrospective studies.

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Al-Hinnawi, AR.M., Al-Naami, B.O. & Al-Latayfeh, M.M. Optic nerve head slope-based quantitative parameters for identifying open-angle glaucoma on SPECTRALIS OCT images. Int Ophthalmol 37, 979–988 (2017). https://doi.org/10.1007/s10792-016-0362-9

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  • DOI: https://doi.org/10.1007/s10792-016-0362-9

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