Abstract
The purpose of this study was to evaluate choroidal thickness (CT) in patients with psoriasis using enhanced depth imaging optical coherence tomography (EDI-OCT) and to determine its relationship with psoriasis activity indices. In this prospective study, EDI-OCT images were obtained in consecutive patients with psoriasis and in age–gender-matched healthy individuals. Comprehensive ophthalmic examination and EDI-OCT evaluation were performed. CT was measured in the subfoveal area. Correlation analyses were performed to identify the relationship of the CT with disease duration and clinical disease activity score. In total, 65 individuals were evaluated in this study, 35 with psoriasis and 30 controls. The mean disease duration of the patients with psoriasis was 15.7 ± 8.8 years (0.3–34 years). There was no difference between groups with respect to age and gender (p = 0.695 and p = 0.628, respectively). Five of the 35 patients with psoriasis had anterior uveitis. None of the patients with psoriasis had signs of posterior uveitis. CT was significantly higher in the psoriasis group than that of control subjects (p < 0.001). The mean central foveal thickness was comparable between groups (p = 0.672). There was also no significant correlation between EDI-OCT, disease activity score, and disease duration (p < 0.05). Choroidal thickness is increased in psoriasis patients. Large serial and comparative studies are necessary to evaluate EDI-OCT, an examination that may be helpful in understanding the effects of psoriasis on the eye and its pathophysiology.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Yildiz A, Ucmak D, Oylumlu M et al (2014) Assessment of atrial electromechanical delay and P-Wave dispersion in patients with psoriasis. Echocardiography 31:1071–1076. doi:10.1111/echo.12530
Helmick CG, Lee-Han H, Hirsch SC, Baird TL, Bartlett CL (2014) Prevalence of psoriasis among adults in the U.S.: 2003–2006 and 2009–2010 National health and nutrition examination surveys. Am J Prev Med 47:37–45. doi:10.1016/j.amepre.2014.02.012
Kilic B, Dogan U, Parlak AH et al (2013) Ocular findings in patients with psoriasis. Int J Dermatol 52:554–559. doi:10.1111/j.1365-4632.2011.05424.x
Erbagci I, Erbagci Z, Gungor K, Bekir N (2003) Ocular anterior segment pathologies and tear film changes in patients with psoriasis vulgaris. Acta Med Okayama 57:299–303
Knox DL (1979) Psoriasis and intraocular inflammation. Trans Am Ophthalmol Soc 77:210–224
Adhi M, Lau M, Liang MC, Waheed NK, Duker JS (2014) Analysis of the thickness and vascular layers of the choroid in eyes with geographic atrophy using spectral-domain optical coherence tomography. Retina 34:306–312. doi:10.1097/IAE.0b013e3182993e09
Adhi M, Brewer E, Waheed NK, Duker JS (2013) Analysis of morphological features and vascular layers of choroid in diabetic retinopathy using spectral-domain optical coherence tomography. JAMA Ophthalmol 131:1267–1274. doi:10.1001/jamaophthalmol.2013.4321
Spaide RF, Koizumi H, Pozonni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500. doi:10.1016/j.ajo.2008.05.032
Coskun E, Gurler B, Pehlivan Y et al (2013) Enhanced depth imaging optical coherence tomography findings in Behçet disease. Ocul Immunol Inflamm 21:440–445. doi:10.3109/09273948.2013.817591
Kola M, Kalkisim A, Karkucak M et al (2014) Evaluation of choroidal thickness in ankylosing spondylitis using optical coherence tomography. Ocul Immunol Inflamm 22:434–438. doi:10.3109/09273948.2014.928734
Roberts ME, Wright V, Hill AG, Mehra AC (1976) Psoriatic arthritis. Follow-up study. Ann Rheum Dis 35:206–212
Lima FB, Abalem MF, Ruiz DG et al (2012) Prevalence of eye disease in Brazilian patients with psoriatic arthritis. Clinics (Sao Paulo) 67:249–253
Durrani K, Foster CS (2005) Psoriatic uveitis: a distinct clinical entity? Am J Ophthalmol 139:106–111
Kim M, Kim H, Kwon HJ, Kim SS, Koh HJ, Lee SC (2013) Choroidal thickness in Behcet’s uveitis: an enhanced depth imaging-optical coherence tomography and its association with angiographic changes. Investig Ophthalmol Vis Sci 5(54):6033–6039. doi:10.1167/iovs.13-12231
Boehncke WH, Boehncke S, Tobin AM, Kirby B (2011) The ‘psoriatic march’: a concept of how severe psoriasis may drive cardiovascular comorbidity. Exp Dermatol 20:303–307. doi:10.1111/j.1600-0625.2011.01261.x
Tracey D, Klareskog L, Sasso EH, Salfeld JG, Tak PP (2008) Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. Pharmacol Ther 117:244
Jasielska M, Semkova I, Shi X et al (2010) Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization. Investig Ophthalmol Vis Sci 51:3874–3883. doi:10.1167/iovs.09-5003
Shi X, Semkova I, Müther PS, Dell S, Kociok N, Joussen AM (2006) Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization. Exp Eye Res 83:1325–1334
Fong AH, Li KK, Wong D (2011) Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. Retina 31:502–509. doi:10.1097/IAE.0b013e3182083beb
Akkurt ZM, Gümüş H, Aktürk A, Uçmak D, Türkcü FM, Gürsel Özkurt Z, Durmaz MS, Bilici A (2015) Evaluation of orbital arteries with colour Doppler ultrasonography in patients with psoriasis. Clin Exp Dermatol 40:507–512. doi:10.1111/ced.12625
Ilhan N, Ustun N, Tuzcu EA, Coskun M, Yagiz AE, Ilhan O, Parlakfikirer N (2015) Spectral domain-optical coherence tomographic findings in patients with ankylosing spondylitis under anti-tumor necrosis factor-alpha therapy. Cutan Ocul Toxicol 34:222–226. doi:10.3109/15569527.2014.956178
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Türkcü, F.M., Şahin, A., Yüksel, H. et al. Evaluation of choroidal thickness in psoriasis using optical coherence tomography. Int Ophthalmol 36, 851–854 (2016). https://doi.org/10.1007/s10792-016-0212-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10792-016-0212-9