Abstract
Optic nerve glioma is the most common optic nerve tumour. However, it has an unpredictable natural history. The treatment of optic nerve gliomas has changed considerably over the past few years. Chemotherapy and radiation therapy can now stabilize and in some cases improve the vision of patients with optic nerve gliomas. The treatment of optic nerve glioma requires a multi-disciplinary approach where all treatment options may have to be implemented in a highly individualized manner. The aim of this review article is to present current diagnostic and treatment protocols for optic nerve glioma.
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Wilhelm H (2009) Primary optic nerve tumours. Curr Opin Neurol 22(1):11–18
Dutton JJ (1994) Gliomas of the anterior visual pathway. Surv Ophthalmol 38:427–452
Miller NR (2004) Primary tumours of the optic nerve and its sheath. Eye (Lond). 18(11):1026–1037
Cummings TJ, Provenzale JM, Hunter SB, Friedman AM, Klintworth GK, Bigner SH et al (2000) Gliomas of the optic nerve: histological, immunohistochemical (MIB-1 and p53), and MRI analysis. Acta Neuropathol 99:563–570
Sharma A, Mohan K, Saini JS (1990) Haemorrhagic changes in pilocytic astrocytoma of the optic nerve. Orbit 9:29–33
Shapey J, Danesh-Meyer HV, Kaye AH (2011) Diagnosis and management of optic nerve glioma. J Clin Neurosci 18(12):1585–1591
Listernick R, Ferner RE, Liu GT et al (2007) Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations. Ann Neurol 61:189–198
Czyzyk E, Józwiak S, Roszkowski M et al (2003) Optic pathway gliomas in children with and without neurofibromatosis 1. J Child Neurol 18:471–478
Grill J, Laithier V, Rodriguez D et al (2000) When do children with optic pathway tumours need treatment? An oncological perspective in 106 patients treated in a single centre. Eur J Pediatr 159:692–696
Balcer LJ, Liu GT, Heller G et al (2001) Visual loss in children with neurofibromatosis type 1 and optic pathway gliomas: relation to tumor location by magnetic resonance imaging. Am J Ophthalmol 131:442–445
Dutton JJ (1991) Optic nerve gliomas and meningiomas. Neurol Clin 9:163–177
Chung EM, Specht CS, Schroeder JW (2007) From the archives of the AFIP: pediatric orbit tumors and tumorlike lesions: neuroepithelial lesions of the ocular globe and optic nerve. Radiographics 27(4):1159–1186
Becker M, Masterson K, Delavelle J, Viallon M, Vargas MI, Becker CD (2010) Imaging of the optic nerve. Eur J Radiol 74(2):299–313
Barkovich AJ (2005) Pediatric neuroimaging, 4th edn. Lippincott Williams & Wilkins, Philadelphic
Weber AL, Caruso P, Sabates NR (2005) The optic nerve: radiologic, clinical, and pathologic evaluation. Neuroimaging Clin N Am 15(1):175–201
Bianchi-Marzoli S, Brancato R (1994) Tumors of the optic nerve and chiasm. Curr Opin Ophthalmol 5:11–17
Silva MM, Goldman S, Keating G et al (2000) Optic pathway hypothalamic gliomas in children under 3 years of age: the role of chemotherapy. Pediatr Neurosurg 33:151–158
Packer RJ, Ater J, Allen J et al (1997) Carboplatin and vincristine for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 86:747–754
Packer RJ, Lange B, Ater J et al (1993) Carboplatin and vincristine for recurrent and newly diagnosed low-grade gliomas of childhood. J Clin Oncol 11:850–856
Lancaster DL, Hoddes JA, Michalski A et al (2003) Tolerance of nitrosourea-based multiagent chemotherapy regime for low-grade pediatric gliomas. J Neuro-Oncol 63:289–294
Taveras JM, Mount LA, Wood EH (1956) The value of radiation therapy in the management of glioma of the optic nerves and chiasm. Radiology 66:518–528
Montgomery AB, Griffin T, Parker RG et al (1977) Optic nerve glioma: the role of radiation therapy. Cancer 40:2079–2080
Dororetz DE, Blitzer PH, Wang CC et al (1980) Management of glioma of the optic nerve and/or chiasm: an analysis of 20 cases. Cancer 45:1467–1471
Tao ML, Barnes PD, Billett AL et al (1997) Childhood optic chiasm gliomas: radiographic response following radiotherapy and long-term clinical outcome. Int J Radiat Oncol Biol Phys 39(3):579–587
Jenkin D, Angyalfi S, Becker L et al (1993) Optic glioma in children: surveillance, resection, or irradiation? Int J Radiat Oncol Biol Phys 25(2):215–225
Pierce SM, Barnes PD, Loeffler JS et al (1990) Definitive radiation therapy in the management of symptomatic patients with optic glioma. Survival and long-term effects. Cancer 65(1):45–52
Kovalic JJ, Grigsby PW, Shepard MJ et al (1990) Radiation therapy for gliomas of the optic nerve and chiasm. Int J Radiat Oncol Biol Phys 18(4):927–932
Cappelli C, Grill J, Raquin M et al (1998) Long-term follow up of 69 patients treated for optic pathway tumours before the chemotherapy era. Arch Dis Child 79(4):334–338
Shrieve DC, Kooy HM, Tarbell NJ, Loeffler JS (1999) Fractionated stereotactic radiotherapy. In: Alexander E, Maciunas RJ (eds) Advanced neurosurgical navigation. Thieme Medical, Stuttgart, pp 451–454
Combs SE, Schulz-Ertner D, Moschos D et al (2005) Fractionated stereotactic radiotherapy of optic pathway gliomas: tolerance and long-term outcome. Int J Radiat Oncol Biol Phys 62(3):814–819
Lacaze E, Kieffer V, Streri A et al (2003) Neuropsychological outcome in children with optic pathway tumours when first-line treatment is chemotherapy. Br J Cancer 89(11):2038–2044
Chadderton RD, West CG, Schuller S et al (1995) Radiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae. Childs Nerv Syst 11(8):443–448 (erratum in: Childs Nerv Syst 1995 Dec; 11(12):715)
Brauner R, Malandry F, Rappaport R et al (1990) Growth and endocrine disorders in optic glioma. Eur J Pediatr 149(12):825–828
Kestle JR, Hoffman HJ, Mock AR et al (1993) Moyamoya phenomenon after radiation for optic glioma. J Neurosurg 79(1):32–35
Kortmann R-D, Timmermann B, Taylor RE et al (2003) Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part I: treatment modalities of radiation therapy. Strahlenther Onkol 179:509–520
Fouladi M, Wallace D, Langston JW et al (2003) Survival and functional outcome of children with hypothalamic/chiasmatic tumors. Cancer 97:1084–1092
Spoor TC, Kennerdell JS, Martinez Z, Zorub D (1980) Malignant gliomas of the optic nerve pathways. Am J Ophthalmol 89:284–292
Danesh-Meyer HV, Savino PJ, Bilyk JR, Sergott RC (2005) Aggressive glioma of adulthood simulating ischemic optic neuropathy. Arch Ophthalmol 123:694–700
Brodovsky S, ten Hove MW, Pinkerton RM, Ludwin SK, Smith RM (1997) An enhancing optic nerve lesion: malignant glioma of adulthood. Can J Ophthalmol 32:409–413
Gandhi RA, Nair AG (2011) Role of imaging in the management of neuro-ophthalmic disorders. Indian J Ophthalmol 59(2):111–116
Acknowledgments
We would like to acknowledge the contribution of Sumedh S Hoskote, MD; Mayo Clinic, Rochester, MN for the assistance provided and Veena Olma Noronha, MD; VRR Scans, Chennai, India for contributing the radiological images.
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Nair, A.G., Pathak, R.S., Iyer, V.R. et al. Optic nerve glioma: an update. Int Ophthalmol 34, 999–1005 (2014). https://doi.org/10.1007/s10792-014-9942-8
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DOI: https://doi.org/10.1007/s10792-014-9942-8