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Massive anterior chamber involvement after Intra-arterial chemotherapy for retinoblastoma: ultrasound biomicroscopy and histopathology

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Abstract

This case report highlights the usefulness of Ultrasound Biomicroscopy (UBM) in a case of retinoblastoma which showed massive anterior chamber involvement after treatment with intra-arterial chemotherapy. UBM was used to document tumour pseudohypopion, cells in the aqueous humor, implanted clusters of cells on the corneal endothelium, iris nodules, lens capsule deposits and ciliary body invasion. The UBM data, compared with the histopathologic analysis, performed on eye tissue, after enucleation of the affected eye, revealed a significant concordance. UBM may represent an important diagnostic tool in retinoblastoma, when the decision about enucleation of the eye must be made in the absence of histopathologic data.

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Acknowledgments

No financial support was received for this submission.

Conflict of interest

None of the authors has conflict of interest with the submission.

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Authors and Affiliations

  1. Retinoblastoma Referral Center, University of Siena, Siena, Italy

    Sonia De Francesco, Mariacarla De Luca & Theodora Hadjistilianou

  2. San Giuseppe Hospital, University Eye Clinic, Via San Vittore 12, 20123, Milan, Italy

    Francesco Pichi, Andrea Lembo & Paolo Nucci

  3. Department of Biomedical Sciences, University of Siena, Siena, Italy

    Domenico Mastrangelo

  4. Department of Ophthalmology, University of Siena, Siena, Italy

    Anna Paradiso

  5. Department of Human Pathology and Oncology, University of Siena, Siena, Italy

    Paolo Toti

Authors
  1. Sonia De Francesco
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  2. Francesco Pichi
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  3. Andrea Lembo
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  4. Domenico Mastrangelo
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  5. Anna Paradiso
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  6. Mariacarla De Luca
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  7. Paolo Toti
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  8. Paolo Nucci
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  9. Theodora Hadjistilianou
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Corresponding author

Correspondence to Francesco Pichi.

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De Francesco, S., Pichi, F., Lembo, A. et al. Massive anterior chamber involvement after Intra-arterial chemotherapy for retinoblastoma: ultrasound biomicroscopy and histopathology. Int Ophthalmol 34, 967–970 (2014). https://doi.org/10.1007/s10792-014-9905-0

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  • DOI: https://doi.org/10.1007/s10792-014-9905-0

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