Skip to main content

Advertisement

Log in

Review of endogenous endophthalmitis during pregnancy including case series

  • Review
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Endogenous endophthalmitis during pregnancy is a rare condition with few reports of such infections in the peri- and post-partum period. We reviewed the literature on endogenous endophthalmitis in pregnancy and also report a series of four patients who presented to our institution from January 2011 to September 2011. We retrospectively reviewed four patients who developed endogenous endophthalmitis either during pregnancy (two patients) or in the post-partum period (two patients—one after abortion and one after normal term delivery). Presenting visual acuity ranged from finger counting at 3 m to no perception of light. Positive cultures included Bacillus mycoides (vitreous) and Klebsiella pneumoniae (urine). Vitrectomy was performed in three patients. In one patient, the vision improved to 20/20. On reviewing the literature and our experience we concluded that endogenous endophthalmitis related to pregnancy is a rare entity with visual prognosis generally being poor. Fluoroquinolones are best avoided. Cephalosporins and amphotericin B are generally the preferred drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Okada AA, Johnson RP, Liles WC, D’Amico DJ, Baker AS (1994) Endogenous bacterial endophthalmitis. Report of a ten-year retrospective study. Ophthalmology 101:832–838

    PubMed  CAS  Google Scholar 

  2. Wongs JS, Chan TK, Lee HM, Chee SP (2007) Endogenous bacterial endophthalmitis: an east Asian experience and a reappraisal of a severe ocular affliction. Ophthalmology 107:1483–1491

    Article  Google Scholar 

  3. Das T, Kunimoto DY, Sharma S et al (2005) Relationship between clinical presentation and visual outcome in postoperative and posttraumatic endophthalmitis in south central India. Indian J Ophthalmol 53:5–16

    Article  PubMed  Google Scholar 

  4. Tsai CC, Chen SJ, Chung YM, Yu KW, Hsu W (2002) Postpartum endogenous Candida endophthalmitis. J Formos Med Assoc 101:432–436

    PubMed  Google Scholar 

  5. Chen SJ, Chung YM, Liu JH (1998) Endogenous Candida endophthalmitis after induced abortion. Am J Ophthalmol 125:873–875

    Article  PubMed  CAS  Google Scholar 

  6. Håskjold E, von der Lippe B (1987) Endogenous candida endophthalmitis: report of 2 cases. Acta Ophthalmol (Copenh) 65:741–744

    Article  Google Scholar 

  7. Cantrill HL, Rodman WP, Ramsay RC, Knobloch WH (1980) Postpartum Candida endophthalmitis. JAMA 243:1163–1165

    Article  PubMed  CAS  Google Scholar 

  8. Rahman W, Hanson R, Westcott M (2011) A rare case of peripartum endogenous bacterial endophthalmitis. Int Ophthalmol 31:113–115

    Article  PubMed  Google Scholar 

  9. Bandyopadhyay S, Thakur JS, Ray P, Kumar R (2005) High prevalence of bacteriuria in pregnancy and its screening methods in north India. J Indian Med Assoc 103(259–62):66

    Google Scholar 

  10. Jackson TL, Eykyn SJ, Graham EM, Stanford MR (2003) Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases. Surv Ophthalmol 48:403–423

    Article  PubMed  Google Scholar 

  11. Vahey JB, Flynn HW Jr (1991) Results in the management of Bacillus endophthalmitis. Ophthalmic Surg. 22:681–686

    PubMed  CAS  Google Scholar 

  12. Das T, Choudhury K, Sharma S, Jalali S, Nuthethi R (2001) Clinical profile and outcome in Bacillus endophthalmitis. Ophthalmology 108:1819–1825

    Article  PubMed  CAS  Google Scholar 

  13. Essman TF, Flynn HW, Smiddy WE, Brod RD, Murray TG, Davis JL, Rubsamen PE (1997) Treatment outcomes in a 10-year study of endogenous fungal endophthalmitis. Ophthalmic Surg Lasers 28:185–194

    PubMed  CAS  Google Scholar 

  14. Sato Y, Miyasaka S, Shimada H (2001) Prognosis of endogenous fungal endophthalmitis and utility of Ishibashi’s classification. Jpn J Ophthalmol 45:181–186

    Article  PubMed  CAS  Google Scholar 

  15. Rabiah PK, Vitale AT (2003) Noninfectious uveitis and pregnancy. Am J Ophthalmol 136:91–98

    Article  PubMed  Google Scholar 

  16. Nardiello S, Pizzella T, Ariviello R (2002) Risks of antibacterial agents in pregnancy. Infez Med 10:8–15

    PubMed  Google Scholar 

  17. Inman W, Pearce G, Wilton L (1994) Safety of fluconazole in the treatment of vaginal candidiasis. Eur J Clin Pharmacol 46:115–118

    Article  PubMed  CAS  Google Scholar 

  18. Lee BE, Feinberg M, Abraham JJ, Murthy AR (1992) Congenital malformations in an infant born to a woman treated with fluconazole. Pediatr Infect Dis J 11:1062–1064

    Article  PubMed  CAS  Google Scholar 

  19. Pursley TJ, Blomquist IK, Abraham J, Andersen HF, Bartley JA (1996) Fluconazole-induced congenital anomalies in three infants. Clin Infect Dis 22:336–340

    Article  PubMed  CAS  Google Scholar 

  20. Klebanoff MA (2009) The Collaborative perinatal project: a 50 year retrospective. Pediatr Perinat Epidemiol 23:2–8

    Article  Google Scholar 

  21. Moudgal VV, Sobel JD (2003) Antifungal drugs in pregnancy: a review. Expert Opin Drug Saf 2:475–483

    Article  PubMed  CAS  Google Scholar 

  22. Das T, Sharma S. Hyderabad Endophthalmitis Research Group (2003) Current management strategies of acute postoperative endophthalmitis. Semin Ophthalmol 18:109–115

    Google Scholar 

  23. Lipsky BA, Baker CA (1999) Fluoroquinolone toxicity profiles: a review focusing on newer agents. Clin Infect Dis 28:352–364

    Article  PubMed  CAS  Google Scholar 

  24. Spencer JP, Gonzalez LS 3rd, Barnhart DJ (2001) Medications in the breast feeding mother. Am Fam Physician 64:119–126

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the Hyderabad Eye Research Foundation and Hyderabad Eye Institute.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Subhadra Jalali.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sahu, C., Kumar, K., Sinha, M.K. et al. Review of endogenous endophthalmitis during pregnancy including case series. Int Ophthalmol 33, 611–618 (2013). https://doi.org/10.1007/s10792-012-9697-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-012-9697-z

Keywords

Navigation