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Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced osteoarthritis

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Abstract

Objective

The aim of the present study was to investigate anti-inflammatory activity of Diclocor in the setting of collagen-induced osteoarthritis in rats in comparison with its active monocomponents—diclofenac sodium and quercetin.

Methods

The study was conducted on the model of collagen-induced osteoarthritis and included measurement of sialic acids, glycoproteins, C-reactive protein, prostaglandin E2, 6-keto-prostaglandin F1α, thromboxane B2, and leukotriene B4. Lastly, morphologic study with morphometry was also performed.

Results

Diclocor is superior to quercetin and diclofenac sodium by the degree of pharmacological effect on some of the studied parameters. The differences between the values were statistically significant.

Conclusion

Diclocor is a promising corrector of inflammatory and destructive joint diseases. Owing to the presence of both diclofenac sodium and quercetin in its composition, Diclocor exhibits a complex mechanism of anti-inflammatory action affecting cyclooxygenase and lipoxygenase ways of arachidonic acid biotransformation.

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Authors and Affiliations

  1. National University of Pharmacy, 27 Pushkinska Str., Kharkiv, 61057, Ukraine

    I. A. Zupanets, S. K. Shebeko & O. S. Popov

  2. PJSC SIC “Borshchahivskiy CPP”, Kyiv, Ukraine

    A. S. Shalamay

Authors
  1. I. A. Zupanets
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  2. S. K. Shebeko
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  3. O. S. Popov
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  4. A. S. Shalamay
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Corresponding author

Correspondence to O. S. Popov.

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The authors declare that they have no conflict of interest.

Ethical approval

All applicable international, national, and institutional guidelines for the care and use of animals were followed. All animal studies were performed in accordance with Directive 2010/63/EU on the protection of animals used for scientific purposes. The plan of this study was approved by the Ethical Committee of National University of Pharmacy, Kharkiv, Ukraine.

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Zupanets, I.A., Shebeko, S.K., Popov, O.S. et al. Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced osteoarthritis. Inflammopharmacol 24, 53–57 (2016). https://doi.org/10.1007/s10787-015-0258-8

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  • DOI: https://doi.org/10.1007/s10787-015-0258-8

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