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Hyperleptinemia: Implications on the Inflammatory State and Vascular Protection in Obese Adolescents Submitted to an Interdisciplinary Therapy

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Abstract

The low-grade systemic inflammation seen in obesity may affect the actions of some adipose tissue-derived adipokines that are involved in the regulation of vascular function. We sought to verify whether hyperleptinemia may influence the inflammatory and atherogenic responses in obese adolescents undergoing interdisciplinary therapy. Thirty-four obese adolescents underwent interdisciplinary therapy for 1 year. Subjects were considered hyperleptinemic if they had baseline values of leptin above 20 ng/mL for boys and 24 ng/mL for girls. Both groups showed an improvement in body composition and a reduction in carotid intima-media thickness. However, only subjects in the non-hyperleptinemic group showed an increase in adiponectin concentration after therapy. Moreover, leptin concentration was positively correlated with adiponectin and inversely correlated with PAI-1 in this group. Hyperleptinemic state may impair the attenuation of inflammation in obese adolescents undergoing interdisciplinary therapy, particularly by impeding the increase in adiponectin concentration, which is directly involved in vascular protection.

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Acknowledgments

We would like to thank the patients that participated of the study.

Grants

This study was supported in part by research grants from: AFIP; FAPESP 2008/53069-0; FAPESP 2011/50356-0, FAPESP 2011/50414-0; FAPESP (CEPID/Sleep #9814303-3 S.T); CNPq; CAPES (AUX-PE-PNPD 2566/2011); CEPE, FADA, and UNIFESP.

Disclosures

No conflicts of interest are reported by the author(s).

Author information

Authors and Affiliations

  1. Post-graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo, Brazil

    Priscila L. Sanches, Marco T. de Mello, Raquel M. S. Campos, June Carnier, Aline de Piano, Deborah C. L. Masquio, Patrícia L. Silva, Flavia C. Corgosinho, Cláudia M. O. Nascimento, Carolina Ackel D’Elia & Ana R. Dâmaso

  2. Psychobiology Department, Universidade Federal de São Paulo, São Paulo, Brazil

    Marco T. de Mello & Sergio Tufik

  3. Association Found of Incentive to Research, Universidade Federal de São Paulo, São Paulo, Brazil

    Marco T. de Mello, Natália Elias & Sergio Tufik

  4. Cardiology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil

    Francisco A. H. Fonseca

  5. Physiology Department, Universidade Federal de São Paulo, São Paulo, Brazil

    Lila M. Oyama & Cláudia M. O. Nascimento

  6. Post-graduate Program of Interdisciplinary Health Sciences, Santos, Brazil

    Ana R. Dâmaso

  7. Biosciences Department, Universidade Federal de São Paulo, São Paulo, Brazil

    Ana R. Dâmaso

  8. Universidade Federal de São Paulo, São Paulo, Brazil

    Lian Tock

  9. Rua Prof. Francisco de Castro, 93–Vila Clementino, São Paulo, SP, Brazil, 04020-050

    Ana R. Dâmaso

Authors
  1. Priscila L. Sanches
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  2. Marco T. de Mello
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  3. Natália Elias
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  7. Aline de Piano
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  8. Deborah C. L. Masquio
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  10. Lila M. Oyama
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  11. Flavia C. Corgosinho
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  14. Carolina Ackel D’Elia
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  16. Ana R. Dâmaso
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Corresponding author

Correspondence to Ana R. Dâmaso.

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Sanches, P.L., de Mello, M.T., Elias, N. et al. Hyperleptinemia: Implications on the Inflammatory State and Vascular Protection in Obese Adolescents Submitted to an Interdisciplinary Therapy. Inflammation 37, 35–43 (2014). https://doi.org/10.1007/s10753-013-9709-9

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  • DOI: https://doi.org/10.1007/s10753-013-9709-9

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