Abstract
It was reported that O glycosylation is associated with hepatic stellate cell activation and regulates collagen expression. In this study, we aimed to investigate the effect of O glycosylation on the activation of human hepatic stellate cells. We found that the inhibitor of O glycosylation, benzyl-α-GalNAc (2 and 4 mM), could significantly inhibit cells proliferation in a dose-dependent manner. Moreover, benzyl-α-GalNAc decreased the expressions of α-smooth muscle actin, collagen I, and collagen III. The results indicate that O glycosylation is involved in the activation of hepatic stellate cells.
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This work was supported by grants from the National Natural Science Foundation of China (30901273).
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Fan, X., Chuan, S. & Hongshan, W. Protein O Glycosylation Regulates Activation of Hepatic Stellate Cells. Inflammation 36, 1248–1252 (2013). https://doi.org/10.1007/s10753-013-9662-7
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DOI: https://doi.org/10.1007/s10753-013-9662-7