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Sinomenine Decreases MyD88 Expression and Improves Inflammation-Induced Joint Damage Progression and Symptoms in Rat Adjuvant-Induced Arthritis

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Abstract

Sinomenine (SIN) is the active principle of the Chinese medical plant Sinomenium acutum which is widely used for the treatment of rheumatoid arthritis (RA) in China. Recently, several groups indicated that myeloid differentiation primary response protein 88 (MyD88) might be associated with disease progression of RA. Here, we observed the effect of SIN on MyD88 expression and showed its therapeutic role in RA. First, immunohistochemical staining in clinical specimens showed that MyD88 was mainly located in characteristic pathological structures of RA synovial tissues. Second, we found that MyD88 was overexpressed in the synovial tissues of the rats with adjuvant-induced arthritis (AIA). Treatment with SIN markedly decreased the expression of MyD88 in AIA rats. Finally, we provided evidences that SIN suppressed inflammation response and inflammation-induced joint destructive progression and arthritis symptoms in AIA rats. Therefore, SIN is an effective therapeutic agent for RA. Targeting MyD88 signaling may provide new methods for the treatment of RA.

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ACKNOWLEDGMENTS

We would particularly like to thank Zi-xiang Cong who has guided us through all stages of the project. This work was supported by grants from the Jinling Hospital of Nanjing (grant no. 2012014).

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The authors declare no competing financial interests.

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Authors and Affiliations

  1. Department of Integrated Traditional and Western Medicine, Jinling Hospital, School of Medicine, Second Military Medical University (Shanghai), Nanjing, 210002, People’s Republic of China

    Hui Mu

  2. Department of Integrated Traditional and Western Medicine, Jinling Hospital, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China

    Ru-Bing Yao, Ling-Jie Zhao, Si-Yu Shen, Zhi-Ming Zhao & Hui Cai

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  1. Hui Mu
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  2. Ru-Bing Yao
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  3. Ling-Jie Zhao
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Correspondence to Hui Cai.

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Mu, H., Yao, RB., Zhao, LJ. et al. Sinomenine Decreases MyD88 Expression and Improves Inflammation-Induced Joint Damage Progression and Symptoms in Rat Adjuvant-Induced Arthritis. Inflammation 36, 1136–1144 (2013). https://doi.org/10.1007/s10753-013-9648-5

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