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Sialylation of cell surface glycoconjugates modulates cytosolic galectin-mediated responses upon organelle damage

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Abstract

Sialylation is an important terminal modification of glycoconjugates that mediate diverse functions in physiology and disease. In this review we focus on how altered cell surface sialylation status is sensed by cytosolic galectins when the integrity of intracellular vesicles or organelles is compromised to expose luminal glycans to the cytosolic milieu, and how this impacts galectin-mediated cellular responses. In addition, we discuss the roles of mammalian sialidases on the cell surface, in the organelle lumen and cytosol, and raise the possibility that intracellular glycan processing may be critical in controlling various galectin-mediated responses when cells encounter stress.

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Funding

This work was supported by Academia Sinica and the Ministry of Science and Technology in Taiwan (MOST 109-2320-B-001-024-MY3).

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Author notes

  1. I-Chun Weng and Hung-Lin Chen contributed equally to this work.

Authors and Affiliations

  1. Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan

    I-Chun Weng

  2. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Hung-Lin Chen

  3. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

    Wei-Han Lin & Fu-Tong Liu

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  1. I-Chun Weng
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  2. Hung-Lin Chen
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  3. Wei-Han Lin
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  4. Fu-Tong Liu
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ICW and HLC wrote the manuscript, FTL edited the manuscript, WHL prepared the figure. All authors reviewed the manuscript.

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Correspondence to Fu-Tong Liu.

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Weng, IC., Chen, HL., Lin, WH. et al. Sialylation of cell surface glycoconjugates modulates cytosolic galectin-mediated responses upon organelle damage. Glycoconj J 40, 295–303 (2023). https://doi.org/10.1007/s10719-023-10112-z

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  • DOI: https://doi.org/10.1007/s10719-023-10112-z

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