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Hereditary gastric cancer: what’s new? Update 2013–2018

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Abstract

Around 10–20% of gastric cancer patients have relatives with a diagnosis of GC and in 1–3% of patients a genetic cause can be confirmed. Histopathologically, GC is classified into intestinal-type, with glandular growth, and diffuse-type with poorly cohesive growth pattern often with signet ring cells. Familial or hereditary GC is classified into hereditary diffuse GC (HDGC), familial intestinal GC (FIGC) and polyposis forms. This review focuses on recent research findings and new concepts of hereditary GC.

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Authors and Affiliations

  1. Department of Pathology, Radboud university medical centre, Nijmegen, The Netherlands

    Rachel S. van der Post

  2. i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Júlio Amaral de Carvalho, 45, 4200-135, Porto, Portugal

    Carla Oliveira & Fátima Carneiro

  3. Ipatimup - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal

    Carla Oliveira & Fátima Carneiro

  4. Faculty of Medicine, University of Porto, Porto, Portugal

    Carla Oliveira & Fátima Carneiro

  5. Cancer Genetics Laboratory, Department of Biochemistry, Centre for Translational Cancer Research, Te Aho Matatū, University of Otago, Dunedin, Aotearoa, New Zealand

    Parry Guilford

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  1. Rachel S. van der Post
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  2. Carla Oliveira
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  3. Parry Guilford
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  4. Fátima Carneiro
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Correspondence to Fátima Carneiro.

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van der Post, R.S., Oliveira, C., Guilford, P. et al. Hereditary gastric cancer: what’s new? Update 2013–2018. Familial Cancer 18, 363–367 (2019). https://doi.org/10.1007/s10689-019-00127-7

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  • DOI: https://doi.org/10.1007/s10689-019-00127-7

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