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10 K: a large‐scale prospective longitudinal study in Israel

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Abstract

The 10 K is a large-scale prospective longitudinal cohort and biobank that was established in Israel. The primary aims of the study include development of prediction models for disease onset and progression and identification of novel molecular markers with a diagnostic, prognostic and therapeutic value. The recruitment was initiated in 2018 and is expected to complete in 2021. Between 28/01/2019 and 13/12/2020, 4,629 from the expected 10,000 participants were recruited (46 %). Follow-up visits are scheduled every year for a total of 25 years. The cohort includes individuals between the ages of 40 and 70 years. Predefined medical conditions were determined as exclusions. Information collected at baseline includes medical history, lifestyle and nutritional habits, vital signs, anthropometrics, blood tests results, Electrocardiography, Ankle–brachial pressure index (ABI), liver US and Dual-energy X-ray absorptiometry (DXA) tests. Molecular profiling includes transcriptome, proteome, gut and oral microbiome, metabolome and immune system profiling. Continuous measurements include glucose levels using a continuous glucose monitoring device for 2 weeks and sleep monitoring by a home sleep apnea test device for 3 nights. Blood and stool samples are collected and stored at − 80 °C in a storage facility for future research. Linkage is being established with national disease registries.

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Data Availability

Access to the 10 K cohort is currently not available online. Potential collaborators are encouraged to contact the Principal Investigator by e-mail (eran.segal@weizmann.ac.il) for further information.

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Acknowledgements

The authors wish to acknowledge all participants of the cohort and the members of the Segal lab for fruitful discussions.

Funding

E.S. is supported by the Crown Human Genome Center; Larson Charitable Foundation New Scientist Fund; Else Kroener Fresenius Foundation; White Rose International Foundation; Ben B. and Joyce E. Eisenberg Foundation; Nissenbaum Family; Marcos Pinheiro de Andrade and Vanessa Buchheim; Lady Michelle Michels; Aliza Moussaieff; and grants funded by the Minerva foundation with funding from the Federal German Ministry for Education and Research and by the European Research Council and the Israel Science Foundation.

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Authors and Affiliations

  1. Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

    Smadar Shilo, Noam Bar, Ayya Keshet, Yeela Talmor-Barkan, Hagai Rossman, Anastasia Godneva, Yochai Edlitz, Dmitry Kolobkov, Bat Chen Wolf, Maya Lotan-Pompan, Kohava Levi, Ori Cohen, Hila Saranga, Adina Weinberger & Eran Segal

  2. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

    Smadar Shilo, Noam Bar, Ayya Keshet, Yeela Talmor-Barkan, Hagai Rossman, Anastasia Godneva, Yochai Edlitz, Dmitry Kolobkov, Bat Chen Wolf, Maya Lotan-Pompan, Kohava Levi, Hila Saranga, Adina Weinberger & Eran Segal

  3. Pediatric Diabetes Clinic, Institute of Diabetes, Endocrinology and Metabolism, Rambam Health Care Campus, Haifa, Israel

    Smadar Shilo

  4. Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel

    Yeela Talmor-Barkan & Yaron Aviv

  5. Department of Cardiology, Rabin Medical Center, Petah-Tikva, Israel

    Yeela Talmor-Barkan & Yaron Aviv

  6. Tel Aviv Sourasky Medical Center, Lis Hospital for Women, Tel Aviv, Israel

    Lee Reicher

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  1. Smadar Shilo
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  2. Noam Bar
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  3. Ayya Keshet
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  4. Yeela Talmor-Barkan
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  5. Hagai Rossman
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  6. Anastasia Godneva
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  7. Yaron Aviv
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  8. Yochai Edlitz
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  9. Lee Reicher
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  10. Dmitry Kolobkov
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  11. Bat Chen Wolf
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  12. Maya Lotan-Pompan
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  13. Kohava Levi
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  14. Ori Cohen
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  15. Hila Saranga
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  16. Adina Weinberger
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  17. Eran Segal
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Corresponding author

Correspondence to Eran Segal.

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All author declares that they have no conflict of interest.

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All participants provided written informed consent.

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Ethics approval was granted by the Institutional Review Board (IRB) of the Weizmann Institute of Science.

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Shilo, S., Bar, N., Keshet, A. et al. 10 K: a large‐scale prospective longitudinal study in Israel. Eur J Epidemiol 36, 1187–1194 (2021). https://doi.org/10.1007/s10654-021-00753-5

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  • DOI: https://doi.org/10.1007/s10654-021-00753-5

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