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“Bad luck” hypothesis and cancer prevention: translating the debate to more actions

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References

  1. Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW. Cancer genome landscapes. Science. 2013;339(6127):1546–58. https://doi.org/10.1126/science.1235122.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019. https://doi.org/10.3322/caac.21551.

    Article  PubMed  Google Scholar 

  3. Song M, Vogelstein B, Giovannucci EL, Willett WC, Tomasetti C. Cancer prevention: molecular and epidemiologic consensus. Science. 2018;361(6409):1317–8. https://doi.org/10.1126/science.aau3830.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015;347(6217):78–81. https://doi.org/10.1126/science.1260825.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Song M, Giovannucci EL. Cancer risk: many factors contribute. Science. 2015;347(6223):728–9. https://doi.org/10.1126/science.aaa6094.

    Article  CAS  PubMed  Google Scholar 

  6. Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017;355(6331):1330–4. https://doi.org/10.1126/science.aaf9011.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Song M, Giovannucci E. Preventable incidence and mortality of carcinoma associated with lifestyle factors among white adults in the United States. JAMA Oncol. 2016;2(9):1154–61. https://doi.org/10.1001/jamaoncol.2016.0843.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature. 2013;500(7463):415–21. https://doi.org/10.1038/nature12477.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Alexandrov LB, Ju YS, Haase K, et al. Mutational signatures associated with tobacco smoking in human cancer. Science. 2016;354(6312):618–22. https://doi.org/10.1126/science.aag0299.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Letouze E, Shinde J, Renault V, et al. Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis. Nat Commun. 2017;8(1):1315. https://doi.org/10.1038/s41467-017-01358-x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Govindan R, Ding L, Griffith M, et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell. 2012;150(6):1121–34. https://doi.org/10.1016/j.cell.2012.08.024.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Funding

This work was supported by the National Institutes of Health (K99CA215314 and R00CA215314) and the American Cancer Society (MRSG-17-220-01 – NEC).

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Authors and Affiliations

  1. Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, 667 Huntington Avenue, Kresge 906A, Boston, MA, 02115, USA

    Mingyang Song

  2. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Mingyang Song

  3. Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA

    Mingyang Song

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  1. Mingyang Song
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Correspondence to Mingyang Song.

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Song, M. “Bad luck” hypothesis and cancer prevention: translating the debate to more actions. Eur J Epidemiol 34, 447–449 (2019). https://doi.org/10.1007/s10654-019-00489-3

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