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Transcriptional toxicity of the Yangtze River source water on mouse (Mus musculus) detected by cDNA microarray

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Abstract

In order to assess the potential health effects of source water from the Yangtze River at Nanjing section, China, hepatic transcriptional profiles of male mice (Mus musculus) exposed to source water for 90 days were measured with Affymetrix Mouse Genome 430A 2.0 Array. A total of 585 gene expressions were significantly altered (1.5-fold, P ≤ 0.05), including 298 up-regulated genes and 287 down-regulated genes. Among the identified genes, potentially important genes that may be implicated in the liver cancer were found, including VCAM 1, Dusp1, Cyp7a1, Egfr and Fhit. The source water exposure also resulted in significant aberration of gene expressions and biological pathways linking to xenobiotic metabolism, signal transduction, cell growth and death, immune/inflammation response and oxidative stress response. The results provide excellent insights into early toxic effects of the Yangtze River source water on human and environmental health.

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Acknowledgments

This research work was financially supported by Engineering Center of Water treatment and Environment Remediation at National Education Ministry of China (WTWER0720), Department of Science and Technology for Jiangsu Province of China (BZ2007064) and The Environmental Monitoring Center of Jiangsu Province (0711).

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Authors and Affiliations

  1. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210093, Nanjing, China

    Bing Wu, Shupei Cheng, Jie Kong, Dayong Zhao, Yan Zhang & Xuxiang Zhang

  2. Environmental Monitoring Center of Jiangsu Province, 210036, Nanjing, China

    Yiqiang Li

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  1. Bing Wu
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  2. Shupei Cheng
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  3. Yiqiang Li
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  4. Jie Kong
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  6. Yan Zhang
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  7. Xuxiang Zhang
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Correspondence to Xuxiang Zhang.

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Wu, B., Cheng, S., Li, Y. et al. Transcriptional toxicity of the Yangtze River source water on mouse (Mus musculus) detected by cDNA microarray. Ecotoxicology 18, 715–721 (2009). https://doi.org/10.1007/s10646-009-0339-9

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  • DOI: https://doi.org/10.1007/s10646-009-0339-9

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