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The effect of contrast reduction on pattern-reversal VEPs in suspected multiple sclerosis and optic neuritis

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Abstract

A retrospective study was conducted to investigate whether the use of low-contrast stimuli in addition to the standard high-contrast stimuli would increase the sensitivity of the pattern-reversal P100 when testing for multiple sclerosis (MS) and optic neuritis (ON). We found that there was a statistically significant increase in the number of abnormal results when using 25′ checks, but not for 50′ checks. Examination of patient records showed that VEP abnormalities to low-contrast stimuli only was not prognostic for subsequent development of multiple sclerosis.

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Authors and Affiliations

  1. Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK

    Adrian W. Davidson & Keith W. Mitchell

  2. The University of Newcastle Upon Tyne, UK

    Richard F. Scott

Authors
  1. Adrian W. Davidson
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  2. Richard F. Scott
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  3. Keith W. Mitchell
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Correspondence to Adrian W. Davidson.

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Davidson, A.W., Scott, R.F. & Mitchell, K.W. The effect of contrast reduction on pattern-reversal VEPs in suspected multiple sclerosis and optic neuritis. Doc Ophthalmol 109, 157–161 (2004). https://doi.org/10.1007/s10633-004-3831-9

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  • DOI: https://doi.org/10.1007/s10633-004-3831-9

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