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Adenoma Prevalence and Distribution Among US Latino Subgroups Undergoing Screening Colonoscopy

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Abstract

Background

Colorectal cancer (CRC) is the second leading malignancy diagnosed among US Latinos. Latinos in the USA represent a heterogeneous amalgam of subgroups varying in genetic background, culture, and socioeconomic status. Little is known about the frequency of CRC precursor lesions found at screening colonoscopy among Latino subgroups.

Aim

The aim was to determine the prevalence and distribution of histologically confirmed adenomas found at screening colonoscopy among average-risk, asymptomatic US Latinos according to their subgroup and socio-demographic background.

Methods

Cross-sectional analysis of pathological findings resulting from screening colonoscopy among average-risk, asymptomatic US Latinos aged ≥50 in two prospective randomized controlled trials at an academic medical center.

Results

Among the 561 Latinos who completed screening colonoscopy, the two largest subgroups were Puerto Ricans and Dominicans. The findings among both subgroups were: adenomas 30.6%, proximal adenomas 23.5%, advanced adenomas 12.0%, and proximal advanced adenomas 8.9%. These rates are at least as high as those found at screening colonoscopy among US whites. While Puerto Ricans were more likely than Dominicans to be born in the USA, speak English, be acculturated, have a smoking history, and be obese, there were no significant differences in adenoma rates between these subgroups.

Conclusions

The prevalence of adenomas, advanced adenomas, and proximal neoplasia was high among both subgroups. These findings have implications for CRC screening and surveillance among the increasingly growing Latino population in the USA.

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Acknowledgments

This study was supported by National Cancer Institute Grant R01 CA140737-01A2 and an independent investigator grant to Sumedha V. Chablani from the Digestive Disease Research Foundation. The contents of this article are solely the responsibility of the authors and do not represent the views of the awarding agencies. The authors thank the study participants and research staff of recruiters and navigators.

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Authors and Affiliations

  1. UPMC Montefiore Hospital, N715, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Sumedha V. Chablani

  2. Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1130, New York, NY, 10029, USA

    Lina Jandorf, Pathu Sriphanlop & Cristina Villagra

  3. Department of Psychiatry, Memorial Sloan Kettering Cancer Center, 641 Lexington Avenue, 7th Floor, New York, NY, 10022, USA

    Katherine DuHamel

  4. Digestive Healthcare Center, 511 Courtyard Drive, Building 500, Hillsborough, NJ, 08844, USA

    Kristen K. Lee

  5. Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1069, New York, NY, 10029, USA

    Steven H. Itzkowitz

  6. Departments of Gastroenterology and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Sumedha V. Chablani, Lina Jandorf, Katherine DuHamel, Kristen K. Lee, Pathu Sriphanlop, Cristina Villagra & Steven H. Itzkowitz

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  1. Sumedha V. Chablani
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  2. Lina Jandorf
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Corresponding author

Correspondence to Sumedha V. Chablani.

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Conflict of interest

Lina Jandorf has received research support from Exact Sciences Corporation. Steven H. Itzkowitz has served on the Scientific Advisory Board of and has received research support from Exact Sciences Corporation. For the remaining authors, no conflicts of interest were declared.

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Chablani, S.V., Jandorf, L., DuHamel, K. et al. Adenoma Prevalence and Distribution Among US Latino Subgroups Undergoing Screening Colonoscopy. Dig Dis Sci 62, 1637–1646 (2017). https://doi.org/10.1007/s10620-016-4381-1

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  • DOI: https://doi.org/10.1007/s10620-016-4381-1

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