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Assessment of Gastric Emptying in Patients with Autoimmune Gastritis

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Abstract

Background and Aim

Symptoms of patients with autoimmune gastritis are not specific, and some patients may present symptoms suggestive of delayed gastric emptying. This study aims to investigate whether any delay in gastric emptying of solid food exists in patients with autoimmune gastritis and, if so, to identify the factors that might affect delayed gastric emptying.

Methods

A total of 165 patients (106 women) diagnosed as having autoimmune gastritis were analyzed by means of a gastric emptying test. All patients underwent a standardized scintigraphic gastric emptying study. Patients with delayed gastric emptying and normal gastric emptying tests were then compared by means of factors that might affect gastric emptying. Also 65 patients with functional dyspepsia who had a gastric emptying study constituted the control group.

Results

The median gastric emptying T ½ time was 127.43 min (min–max 50–953) for patients with AIG and 81 min (min–max 21–121.6) for functional dyspepsia patients (p < 0.001), and median percent retention at 2 h was 63.8 versus 20.2 (p < 0.001). In multivariate analysis, parameters that affected gastric emptying T ½ time were found as serum gastrin level (OR 1.002, 95 % CI 1.001–1.004, p < 0.001, chronic inflammation (OR 3.689, 95 % CI 1.44–9.39, p < 0.001), and increase in the degree of the atrophy of the gastric mucosa (OR 8.96, 95 % CI 2.98–26.93, p < 0.001).

Conclusions

In patients with autoimmune gastritis, gastric emptying is generally delayed. Autoimmune gastritis is an important etiology to explain the finding of delayed gastric emptying on a radionuclide test. This new finding is likely to be relevant to clinicians when evaluating and initiating appropriate medical treatment for patients with autoimmune gastritis manifesting upper gastrointestinal symptoms.

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Acknowledgments

The authors would like to thank Zeynep B. Gençtürk for her statistical assistance.

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Authors and Affiliations

  1. Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkey

    Çağdaş Kalkan, Irfan Soykan & Emra Kalkan

  2. Department of Nuclear Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey

    Çiğdem Soydal & Elgin Özkan

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  1. Çağdaş Kalkan
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  2. Irfan Soykan
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  3. Çiğdem Soydal
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  4. Elgin Özkan
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  5. Emra Kalkan
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Correspondence to Irfan Soykan.

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Kalkan, Ç., Soykan, I., Soydal, Ç. et al. Assessment of Gastric Emptying in Patients with Autoimmune Gastritis. Dig Dis Sci 61, 1597–1602 (2016). https://doi.org/10.1007/s10620-015-4021-1

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  • DOI: https://doi.org/10.1007/s10620-015-4021-1

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