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Stimulation of Calcitonin Gene-Related Peptide Release Through Targeting Capsaicin Receptor: A Potential Strategy for Gastric Mucosal Protection

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Abstract

Calcitonin gene-related peptide (CGRP) is a predominant neurotransmitter from capsaicin-sensitive sensory nerves, which are widely distributed in the gastrointestinal system. These sensory nerves are reported to be involved in the protection of gastric mucosa against damage by various stimuli, and CGRP is a potential mediator in this process. In addition to increase in gastric mucosal blood flow, the beneficial effects of CGRP on gastric mucosa include inhibition of gastric acid secretion, prevention of cellular apoptosis and oxidative injury. The synthesis and release of CGRP is regulated by the capsaicin receptor which is known as transient receptor potential vanilloid subfamily member 1 (TRPV1) and the agonists of TRPV1 have the potential for gastric mucosal protection. So far, multiple TRPV1 agonists, including capsaicin, capsiate, anandamide and rutaecarpine are reported to exert beneficial effects on gastric mucosal injury induced by various stimuli. Therefore, the TRPV1/CGRP pathway represents a novel target for therapeutic intervention in human gastric mucosal injury.

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Acknowledgments

This work was supported by the Special Fund for National Outstanding Doctoral Dissertation of China (No. 2007B7 to Peng J.), by the National Natural Science Foundation of China (No. 30971194 to Peng J.) and by the Doctoral Fund of Education Ministry of China (No. 200805331118 to Yang Z.C.). We sincerely thank Dr. Qing-Jie Li (Division of Gastroenterology, Department of Internal Medicine, The University of Texas, Medical Branch) for his kind assistance in fixing the language problems in our manuscript.

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  1. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, 110 Xiang-Ya Road, Changsha, 410078, China

    Xiu-Ju Luo, Bin Liu, Zhi-Chun Yang & Jun Peng

  2. Department of Pharmacology, Guangdong Medical College, Dongguan, 523808, Guangdong, China

    Zhong Dai

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  1. Xiu-Ju Luo
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Correspondence to Jun Peng.

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Luo, XJ., Liu, B., Dai, Z. et al. Stimulation of Calcitonin Gene-Related Peptide Release Through Targeting Capsaicin Receptor: A Potential Strategy for Gastric Mucosal Protection. Dig Dis Sci 58, 320–325 (2013). https://doi.org/10.1007/s10620-012-2362-6

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