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Clinical Characteristics of Patients with Hepatitis C Virus-Related Chronic Liver Disease Seropositive for Anticentromere Antibody

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Abstract

The association between anticentromere antibody (ACA) and hepatitis C virus (HCV) infection remains unclear. We subjected eight patients with HCV-related chronic liver disease (CLD) seropositive for ACA to a battery of clinical and laboratory tests. The patient cohort was dominated by females, and four of the eight (50%) patients had a concomitant autoimmune disease. All of the patients had high titers of ACA (≥1:320). The histological activity index scores in chronic hepatitis C (CH-C) patients with ACA were significantly higher than those in CH-C patients without antinuclear antibody (ANA) (12.8 ± 1.8 vs. 8.3 ± 4.5, P = 0.0372). The frequency of human leukocyte antigen (HLA) DR-8 in patients with HCV-related CLD seropositive for ACA was significantly higher than that in patients with CH-C seronegative for ANA (71 vs. 18%, P = 0.0108). These findings suggest that ACA is induced by chronic HCV infection in association with HLA DR-8, and that CH-C patients with ACA exhibit more severe hepatic fibrosis and inflammation than CH-C patients without ANA.

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Authors and Affiliations

  1. Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan

    Takashi Himoto, Seiji Nakai, Fumihiko Kinekawa, Hirohito Yoneyama, Akihiro Deguchi, Kazutaka Kurokochi, Tsutomu Masaki, Mikio Nishioka & Shigeki Kuriyama

  2. Department of Integrated Medicine, Kagawa University School of Medicine, 1750-1, Ikenobe, Miki-Cho, Kita-Gun, Kagawa, 761-0793, Japan

    Takashi Himoto & Shoichi Senda

  3. Department of Diagnosis Pathology, Kagawa University School of Medicine, Kagawa, Japan

    Reiji Haba

  4. Department of Gastroenterology, Kagawa Prefectural Central Hospital, Kagawa, Japan

    Seishiro Watanabe

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  1. Takashi Himoto
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Himoto, T., Nakai, S., Kinekawa, F. et al. Clinical Characteristics of Patients with Hepatitis C Virus-Related Chronic Liver Disease Seropositive for Anticentromere Antibody. Dig Dis Sci 54, 360–368 (2009). https://doi.org/10.1007/s10620-008-0359-y

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