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Rosiglitazone Attenuates Liver Inflammation in a Rat Model of Nonalcoholic Steatohepatitis

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Abstract

Rosiglitazone is an insulin-sensitizing agent. We aimed to assess the effects of rosiglitazone on a methionine- and choline-deficient diet (MCDD) model of nonalcoholic steatohepatitis (NASH) in rats. Wistar rats were fed either MCDD or a control diet in the 4-week induction study; they were given saline or 4 mg/kg/day rosiglitazone. After the induction study period, the rats were divided into four groups and fed MCDD or given a control diet for an additional 8 weeks and received saline or rosiglitazone. Serum and tissue samples were obtained. Rosiglitazone improved inflammation in NASH and improved ALT, alkaline phosphatase, and interleukin-6 levels in the induction study and interleukin-1β, interleukin-6, and tumor necrosis factor-α levels in the treatment study. Our preliminary study is the first to show the anti-inflammatory effects of rosiglitazone in NASH. Rosiglitazone’s effect on cytokines may be a key mechanism of its anti-inflammatory effect in NASH.

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Authors and Affiliations

  1. Department of Gastroenterology, Marmara University School of Medicine, Istanbul, Turkey

    Veysel Tahan, Nese Imeryuz & Nurdan Tozun

  2. Institute of Gastroenterology, Marmara University, Istanbul, Turkey

    Fatih Eren, Erol Avsar, Ebru Emekli & Nurdan Tozun

  3. Department of Endocrinology, Marmara University School of Medicine, Istanbul, Turkey

    Dilek Yavuz

  4. Department of Biochemistry, Marmara University School of Medicine, Istanbul, Turkey

    Meral Yuksel & Goncagul Haklar

  5. Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey

    Cigdem Celikel

  6. Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

    Hafize Uzun

  7. Cavusdere Cad, Huzur Camii Sk, Akman Apt. No. 1/1, Daire 9 Uskudar, 81140, Istanbul, Turkey

    Veysel Tahan

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  1. Veysel Tahan
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  2. Fatih Eren
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Correspondence to Veysel Tahan.

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Tahan, V., Eren, F., Avsar, E. et al. Rosiglitazone Attenuates Liver Inflammation in a Rat Model of Nonalcoholic Steatohepatitis. Dig Dis Sci 52, 3465–3472 (2007). https://doi.org/10.1007/s10620-007-9756-x

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  • DOI: https://doi.org/10.1007/s10620-007-9756-x

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