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Apolipoprotein E Gene Polymorphism in Nonalcoholic Fatty Liver Disease

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Abstract

The aim of this study was to evaluate the relationship between apolipoprotein E gene polymorphism and nonalcoholic fatty liver disease. The study group consisted of 237 nonalcoholic fatty liver disease patients who were detected by ultrasonography and 201 controls with ultrasonographically normal livers. DNA amplifications were performed by polymerase chain reaction technique and apolipoprotein E genotypes were evaluated after digestion with CfoI restriction enzyme. Serum levels of glucose, lipids, lipoproteins, and apolipoproteins were measured in all subjects. Additionally, viral hepatitis markers, liver enzymes, and body mass index were assessed. Patients were found to have significantly higher triglyceride, glucose, aspartate aminotrasferase, alanine aminotransferase, and γ-glutamyltransferase levels and lower high-density lipoprotein cholesterol and apolipoprotein (a) levels than controls (P<0.05). There were no statistically significant differences in genotypes and allele frequencies between all patients and controls. Comparing nonobese patients with controls, the frequencies of allele ε2 and genotype ε2ε3 were statistically significantly different in the controls (P = 0.04 and P = 0.01, respectively). In conclusion, occurrence of the ε2 allele and ε2ε3 genotype may be protective against development of nonalcoholic fatty liver disease.

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Authors and Affiliations

  1. Department of Internal Medicine, Gazi University, School of Medicine, Ankara, Turkey

    Mehmet Derya Demirag

  2. Department of Medical Biology and Genetics, Gazi University, School of Medicine, Ankara, Turkey

    Hacer Ilke Onen & Abdullah Ekmekci

  3. Department of Medical Genetics, Gazi University, School of Medicine, Ankara, Turkey

    Meral Yirmibes Karaoguz

  4. Department of Internal Medicine, Section of Gastroenterology, Gazi University, School of Medicine, Ankara, Turkey

    Ibrahim Dogan & Tarkan Karakan

  5. Department of Internal Medicine, Section of Nephrology, Gazi University, School of Medicine, Ankara, Turkey

    Galip Guz

  6. Gazi Üniversitesi Tıp Fakültesi, Gazi Hastanesi, Besevler/Ankara, 06500, Turkey

    Mehmet Derya Demirag

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  1. Mehmet Derya Demirag
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  2. Hacer Ilke Onen
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  3. Meral Yirmibes Karaoguz
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  4. Ibrahim Dogan
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  5. Tarkan Karakan
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  6. Abdullah Ekmekci
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  7. Galip Guz
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Correspondence to Mehmet Derya Demirag.

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Demirag, M.D., Onen, H.I., Karaoguz, M.Y. et al. Apolipoprotein E Gene Polymorphism in Nonalcoholic Fatty Liver Disease. Dig Dis Sci 52, 3399–3403 (2007). https://doi.org/10.1007/s10620-007-9740-5

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  • DOI: https://doi.org/10.1007/s10620-007-9740-5

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