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Evaluation of Gastric Cancer Risk Using Topography of Histological Gastritis: A Large-scaled Cross-sectional Study

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Abstract

We evaluated the topography of histological gastritis, which may be risk factors for gastric cancer (GCa). A total of 530 Helicobacter pylori-positive patients underwent diagnostic upper-gastrointestinal endoscopy. Biopsy specimens were obtained from the gastric antrum and body to assess the grade of gastritis. Subjects were divided into four groups by the topography of active gastritis (antrum predominant gastritis, AP; pan-gastritis with or without corpus atrophy, Pan-1 and Pan-2; and corpus predominant gastritis, CP). A higher prevalence of GCa followed the order of Pan 2→CP→Pan 1→AP. The age of patients decreased in the same order. When we set Pan 2 and CP as a high-risk group, the sensitivity and specificity for GCa detection were 77.3 and 54.7%, which were superior to the serum criteria using pepsinogens. These suggest that topography of histologic gastritis is an important marker to identify the high-risk group.

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Acknowledgements

We thank Ms. Nao Kubota (Hiroshima University, Japan) for the excellent assistance in the production of the database used in this study. This study was supported by grant from Tsuchiya Research Foundation.

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Authors and Affiliations

  1. Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 734-8551, Japan

    Shinobu Imagawa, Masanori Ito, Yoshihiro Wada, Masana Tatsugami, Akemi Takamura & Kazuaki Chayama

  2. Health Service Center, Hiroshima University, Higashi-Hiroshima, Japan

    Masaharu Yoshihara

  3. Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan

    Shigeto Yoshida & Shinji Tanaka

  4. Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan

    Ken Haruma

Authors
  1. Shinobu Imagawa
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  2. Masaharu Yoshihara
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  3. Masanori Ito
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  4. Shigeto Yoshida
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  5. Yoshihiro Wada
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  6. Masana Tatsugami
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  7. Akemi Takamura
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  8. Shinji Tanaka
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  9. Ken Haruma
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  10. Kazuaki Chayama
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Corresponding author

Correspondence to Masanori Ito.

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Imagawa, S., Yoshihara, M., Ito, M. et al. Evaluation of Gastric Cancer Risk Using Topography of Histological Gastritis: A Large-scaled Cross-sectional Study. Dig Dis Sci 53, 1818–1823 (2008). https://doi.org/10.1007/s10620-007-0077-x

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  • DOI: https://doi.org/10.1007/s10620-007-0077-x

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