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Nodular Gastritis: An Endoscopic Indicator of Helicobacter Pylori Infection

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Abstract

We prospectively assessed the relationship between nodular gastritis and Helicobacter pylori infection. Of 1409 adults who underwent endoscopy for persistent dyspepsia between June 2004 and August 2005, 41 (2.9%) patients were diagnosed with nodular gastritis (11 [27%] men and 30 [73%] women). The mean age was 45.9 years. A control group of 65 patients without nodular gastritis was also evaluated. The prevalence of H. pylori infection was higher in patients with nodular gastritis than in controls (38/41 [93%] vs. 33/65 [51%]). Of 21 patients treated to eradicate H. pylori, the nodular gastritis pattern resolved or improved in 16 patients on subsequent endoscopy. This study suggests that a nodular pattern of the gastric mucosa on endocscopy is a good indicator for H. pylori infection in adults, with the high positive predictive value of 92.7%.

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References

  1. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ (2001) Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 13:784–789

    Article  Google Scholar 

  2. Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, Orentreich N, Vogelman JH, Friedman GD (1994) Helicobacter pylori infection and gastric lymphoma. N Engl J Med 330:1267–1271

    Article  PubMed  CAS  Google Scholar 

  3. Chen XY, Liu WZ, Shi Y, Zhang DZ, Xiao SD, Tytgat GN (2002) Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa. J Clin Pathol 55:133–137

    PubMed  CAS  Google Scholar 

  4. Genta RM, Hamner HW (1994) The significance of lymphoid follicles in the interpretation of gastric biopsy specimens. Arch Pathol Lab Med 118:740–743

    PubMed  CAS  Google Scholar 

  5. Ma ZQ, Tanizawa T, Nihei Z, Sugihara K, Nakamura K (2000) Follicular gastritis associated with Helicobacter pylori. J Med Dent Sci 47:39–47

    PubMed  CAS  Google Scholar 

  6. Miyamoto M, Haruma K, Yoshihara M, Hiyama T, Sumioka M, Nishisaka T, Tanaka S, Chayama K (2003) Nodular gastritis in adults is caused by Helicobacter pylori infection. Dig Dis Sci 48:968–975

    Article  PubMed  Google Scholar 

  7. Riddell RH (1999) Pathobiology of Helicobacter pylori infection in children. Can J Gastroenterol 13:599–603

    PubMed  CAS  Google Scholar 

  8. Oderda G (1999) Transmission of Helicobacter pylori infection. Can J Gastroenterol 13:595–597

    PubMed  CAS  Google Scholar 

  9. Rafeey M, Jafari Rouhi AH, Gassemi BA, Rouhi AJ (2004) Relationship between endoscopic nodular gastritis and Helicobacter pylori infection in children. Indian J Gastroenterol 23:138–139

    PubMed  Google Scholar 

  10. Kato S, Nishino Y, Ozawa K, Konno M, Maisawa S, Toyoda S, Tajiri H, Ida S, Fujisawa T, Iinuma K (2004) The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease. J Gastroenterol 39:734–738

    PubMed  Google Scholar 

  11. Kato S, Sugiyama T, Kudo M, Ohnuma K, Ozawa K, Iinuma K, Asaka M, Blaser MJ (2000) CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease. J Clin Microbiol 38:68–70

    PubMed  CAS  Google Scholar 

  12. Ohara H, Isomoto H, Wen CY, Ejima C, Murata M, Miyazaki M, Takeshima F, Mizuta Y, Murata I, Koji T, Nagura H, Kohno S (2003) Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis. World J Gastroenterol 9:2701–2705

    PubMed  CAS  Google Scholar 

  13. Bahu Mda G, da Silveira TR, Maguilnick I, Ulbrich-Kulczynski J (2003) Endoscopic nodular gastritis: an endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori. J Pediatr Gastroenterol Nutr 36:217–222

    Article  PubMed  Google Scholar 

  14. Kanda M, Ohshima K, Suzumiya J, Haraoka S, Kawasaki C, Sakisaka S, Kikuchi M (2003) Follicular lymphoma of the stomach: immunohistochemical and molecular genetic studies. J Gastroenterol 38:584–587

    PubMed  Google Scholar 

  15. Miyamoto M, Haruma K, Yoshihara M, Sumioka M, Nishisaka T, Tanaka S, Inoue K, Chayama K (2002) Five cases of nodular gastritis and gastric cancer: a possible association between nodular gastritis and gastric cancer. Dig Liver Dis 34:819–820

    Article  PubMed  CAS  Google Scholar 

  16. Nakamura S, Aoyagi K, Furuse M, et al. (1998) B-cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis. Am J Pathol 152:1271–1279

    PubMed  CAS  Google Scholar 

  17. Mitchell HM, Bohane TD, Tobias V, et al. (1993) Helicobacter pylori infection in children: potential clues to pathogenesis. J Pediatr Gastroenterol Nutr 16:120–125

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

The authors would like to thank Dr. Mary Jeanne Buttrey for critical reading and correction of the manuscript.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology, Mackay Memorial Hospital, No. 92, Sec. 2, Chungshan North Road, Taipei, Taiwan

    Ming-Jen Chen, Tsang-En Wang, Wen-Hsiung Chang, Ta-Chuan Liao, Ching-Chung Lin & Shou-Chuan Shih

  2. Mackay Medicine, Nursing and Management College, Taipei, Taiwan

    Ming-Jen Chen, Tsang-En Wang, Wen-Hsiung Chang, Ching-Chung Lin & Shou-Chuan Shih

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  1. Ming-Jen Chen
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  2. Tsang-En Wang
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  3. Wen-Hsiung Chang
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  4. Ta-Chuan Liao
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Correspondence to Ming-Jen Chen.

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Chen, MJ., Wang, TE., Chang, WH. et al. Nodular Gastritis: An Endoscopic Indicator of Helicobacter Pylori Infection. Dig Dis Sci 52, 2662–2666 (2007). https://doi.org/10.1007/s10620-006-9281-3

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  • DOI: https://doi.org/10.1007/s10620-006-9281-3

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