Abstract
Gastric mucosal lesions are very common in portal hypertension and cirrhosis. The aim of this study was to assess for oxidative gastric tissue damage in cirrhosis and evaluate relations with portal hypertension and cirrhosis parameters. The study included 30 patients with cirrhosis and 30 controls. Each patient's history, physical examination, and laboratory findings were recorded, and multiple biopsies of the gastric antrum were obtained at endoscopy. A set of antral biopsies was also collected from each control subject. Each tissue specimen was analyzed for levels of glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) activity and level of malondialdehyde (MDA). Patients’ gastric GPX, SOD, and CAT levels were significantly lower, and MDA levels were higher, than in the control group. The GPX activity level in the specimens was moderately negatively correlated with portal vein diameter (P < 0.05, r=−0.45) and spleen length (P < 0.05, r=−0.45). In this study gastric tissue oxidative markers showed that antral oxidative factors worsen in cirrhosis. Oxidative stress may not be a clinical condition but it obviously shows gastric tissue damage and may explain many patients’ gastric lesions and hemorrhage.
Similar content being viewed by others
References
Lowry OH, Rosebrough NJ, Farr AL (1952) Protein measurements with folin phenol reagent. J Biol Chem 193:265–271
Lawrence RA, Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71(4):952–958
McCord JM, Fridovich I (1969) Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol chem 244(22):6049–6055
Luck H (1963) Methods of enzymatic analysis, 2nd ed., Verlag Cheme, New York, Academic Press, pp 885–888
Mihara M, Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86(1):271–278
Vigneri S, Termini R, Piraino A, Scialabba A, Pisciotta G, Fontana N (1991) The stomach in liver cirrhosis. Endoscopic, morphological, and clinical correlations. Gastroenterology 101:472–478
Merkel C, Schipilliti M, Bighin R, Bellini B, Angeli P, Bolognesi M, Vescovi F, Gatta A (2003) Portal hypertension and portal hypertensive gastropathy in patients with liver cirrhosis:A haemodynamic study. Dig Liver Dis 35:269–274
Vigneri S, Scialabba A, Termini R, Germana B, Vianello F, Grassi SA, Plebani M, Di Mario F (1992) Pathophysiology of the gastric microcirculation. Ital J Gastroenterol 24:22–30
Primignani M, Carpinelli L, Preatoni P, Battaglia G, Carta A, Prada A, Cestari R, Angeli P, Gatta A, Rossi A, Spinzi G, de Franchis R (2000) Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. The New Italian Endoscopic Club for the study and treatment of esophageal varices (NIEC). Gastroenterology 119:181–187
Kitano S, Dolgor B (2000) Does portal hypertension contribute to the pathogenesis of gastric ulcer associated with liver cirrhosis? J Gastroenterol 35:79–86
Tomoda J, Mizuno M, Sugihara T, Itano T, Tsuji T (1989) Gastric mucosal lesion in liver disease: Impaired gastric mucosal defence mechanism in rats with induced liver injury and in patients with liver cirrhosis. J Gastroenterol Hepatol 4(Suppl 1):136–139
Siringo S, Vaira D, Menegatti M, Piscaglia F, Sofia S, Gaetani M, Miglioli M, Corinaldesi R, Bolondi L (1997) High prevalence of Helicobacter pylori in liver cirrhosis: Relationship with clinical and endoscopic features and the risk of peptic ulcer. Dig Dis Sci 42:2024–2030
Lang BH, Poon RT, Fan ST, Wong J (2004) Outcomes of patients with hepatocellular carcinoma presenting with variceal bleeding. Am J Gastroenterol 99:2158–2165
Wu CS, Lin CY, Liaw YF (1995) Helicobacter pylori in cirrhotic patients with peptic ulcer disease:a prospective, case controlled study. Gastrointest Endosc 42:424–427
Tsai CJ (1998) Helicobacter pylori infection and peptic ulcer disease in cirrhosis. Dig Dis Sci 43:1219–1225
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Seckin, Y., Harputluoglu, M.M.M., Batcioglu, K. et al. Gastric Tissue Oxidative Changes in Portal Hypertension and Cirrhosis. Dig Dis Sci 52, 1154–1158 (2007). https://doi.org/10.1007/s10620-006-9139-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10620-006-9139-8