A chemical investigation of the 80% ethanol extract of the roots of Aconitum episcopale led to the isolation of two undescribed C19-diterpenoid alkaloids, designated as episcopines A and B. The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested in vivo for antinociceptive potential. Episcopine A showed a 2-fold more potent antinociceptive effect (ID50 = 66.1 μmol/kg) than the positive control drugs aspirin and acetaminophen.
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ACKNOWLEDGMENT
The above research was made possible by a grant from the joint special fund project of the Applied Basic Research for Local University in Yunnan Province (2019FH001 (-033)), Special funds for reform and development of local university supported by the Central Finance (PL201707230369), and the National Undergraduate Training Programs for Innovation and Entrepreneurship (201910684029).
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2021, pp. 429–431.
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Hu, J., Li, J., Li, Q. et al. Antinociceptive C19-Diterpenoid Alkaloids from Aconitum episcopale. Chem Nat Compd 57, 503–506 (2021). https://doi.org/10.1007/s10600-021-03397-9
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DOI: https://doi.org/10.1007/s10600-021-03397-9