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Isolation of Antimicrobial Peptides from Fritillaria pallidiflora

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Chemistry of Natural Compounds Aims and scope

Polypeptide fractions from seeds of Fritillaria pallidiflora Schrenk were isolated and purified. The peptide compositions and molecular masses were determined using SDS-PAAG electrophoresis and LC-MS analysis. The results showed that the most active fraction of biocidal peptides contained greater than 20 constituents with molecular masses in the range of 1050–4727.2 Da. The isolated peptide fractions exhibited antimicrobial activity against the fungus Candida albicans.

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Acknowledgment

The work was supported financially by the National Scientific Research Program of China (No. U1403201). We thank Central Asian Drug Research and Development Center of Chinese Academy of Sciences, Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, and the Academy of Sciences of the Republic of Uzbekistan for support of the research.

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Authors and Affiliations

  1. Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, 830011, Urumqi Xinjiang, P. R. China

    Y. Mijiti, P. Rozi, Y. H. Gao, A. Yili & H. A. Aisa

  2. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 830011, Urumqi, P. R. China

    A. Waili, Y. H. Gao, A. Yili & H. A. Aisa

  3. University of Chinese Academy of Science, 100039, Beijing, P. R. China

    Y. Mijiti, P. Rozi & A. Waili

  4. A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan, 100125

    V. V. Maksimov, Zh. F. Ziyavitdinov & Sh. I. Salikhov

Authors
  1. Y. Mijiti
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  2. P. Rozi
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  3. A. Waili
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  4. Y. H. Gao
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  5. V. V. Maksimov
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  6. Zh. F. Ziyavitdinov
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  7. A. Yili
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  8. Sh. I. Salikhov
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  9. H. A. Aisa
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Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2017, pp. 972–975.

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Mijiti, Y., Rozi, P., Waili, A. et al. Isolation of Antimicrobial Peptides from Fritillaria pallidiflora . Chem Nat Compd 53, 1144–1147 (2017). https://doi.org/10.1007/s10600-017-2219-5

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  • DOI: https://doi.org/10.1007/s10600-017-2219-5

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