A new isophthalic acid, 2-acetyl-5-hydroxy-6-methoxyisophthalic acid (1), was isolated from the wetland soil-derived fungus Talaromyces flavus (No. BYD07-13). Its chemical structure was elucidated on the basis of UV, IR, MS, and NMR spectroscopic analyses. The anti-Aβ 42 aggregation, cytotoxic, and antimicrobial activities of compound 1 were tested. Compound 1 displayed significant anti-Aβ 42 aggregation activity with a relative inhibitory rate value of 55.01% at a concentration of 100 μmol/mL. This is the first report that isophthalic acid has anti-Aβ 42 agregation activity.
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Acknowledgment
This work was financially supported by the National Natural Science Foundation of China (No. 81503357) and the Jiangxi University of Traditional Chinese Medicine (No. 2014RC003).
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2017, pp. 349–350.
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He, J., Yang, L., Wang, Y. et al. A New Isophthalic Acid from Talaromyces flavus . Chem Nat Compd 53, 409–411 (2017). https://doi.org/10.1007/s10600-017-2010-7
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DOI: https://doi.org/10.1007/s10600-017-2010-7